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Ipamorelin

Ipamorelin

Also called: GHRP

By The Health Stacks Research TeamUpdated July 28, 2026

Ipamorelin is a lab-made substance known as a growth hormone releasing peptide. It belongs to a group of compounds that tell the body to make more natural growth hormone. People who study these compounds often look at them for muscle growth, fat loss, and recovery from injuries. It is important to know that this peptide is not approved by health groups like the FDA for everyday people to use.

Instead, it is sold strictly as a research chemical for scientists to study in labs.This compound works by targeting a specific spot in the body called the ghrelin receptor. When it attaches to this spot, it sends a signal to the brain to release growth hormone in a gentle, natural rhythm. Unlike some other similar lab-made substances, Ipamorelin is known for being very clean. This means it does its job without causing big spikes in stress hormones or other unwanted side effects.

Because of this, researchers find it very interesting to study for body composition and healing.Even though it is popular in research, there is still a lot we do not know about how it works in real human bodies over a long time. Most of the information we have comes from lab studies or reports from people who use it on their own, rather than strict medical trials. Because it is not approved for human use, anyone handling it must be very careful. It should only be used by trained professionals in controlled laboratory environments to ensure safety and proper testing.

Research-stageEarly-stage — studied in cell or animal models, not yet tested in humans. Medium confidence40–59 — backed by moderate-quality sources. Worth a closer look at the individual citations.
Where to Source Ipamorelin
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What Ipamorelin Helps With

The benefits people report — backed by research.

Reproductive & hormonal (33)

Selective GH release 85/100· 2 srcFirst selective growth hormone secretagogue 95/100Selective GH release without cortisol/ACTH/prolactin elevation 95/100Stimulates GH secretion via GHS-R1a receptor 95/100Selective GH stimulation without elevating cortisol, ACTH, or prolactin 95/100Increases IGF-1 levels to young-adult ranges 95/100Selective GH release without cortisol or prolactin elevation 90/100Preservation of natural GH pulsatility 90/100Pulsatile GH Release 90/100No Cortisol/ACTH/Prolactin Elevation 90/100Selective GH release without cortisol/prolactin elevation 90/100Rapid, dose-dependent GH pulse within 20-30 minutes of injection 88/100Minimal Cortisol/Prolactin Elevation 85/100Minimal Influence on Cortisol, Prolactin, and ACTH 85/100Selective GH Release Without Cortisol, Prolactin, or ACTH Elevation 85/100Highly Selective GH Release with Minimal Cortisol and Prolactin Elevation 85/100Pulsatile Growth Hormone Release 85/100Selective GH Release Without Cortisol/ACTH/Prolactin Impact 85/100Enhanced Sexual Function 85/100Minimal Cortisol Impact 85/100Stimulation of natural growth hormone release 85/100Amplifies nocturnal growth hormone pulse 85/100Stimulation of GH secretion without significant increase in cortisol, ACTH, or prolactin 85/100Least Associated with Pituitary Desensitization Among Ghrelin-Receptor Secretagogues 80/100Maintenance of Testicular Function during TRT 80/100Preservation of Hypothalamic-Pituitary Feedback Axis 75/100Counteracting Glucocorticoid Side Effects 75/100Minimal cortisol/ACTH impact 74/100At >200x the GH ED50 it had negligible effect on ACTH/cortisol - the selective profileGH Axis Stimulation via GHRP and GHRH Combination 72/100Most selective GHRP with minimal cortisol/prolactin impact 70/100Additive effects on peak GH secretion markers 60/100Limited interactions with cortisol and prolactin pathways 60/100Stimulation of both GH production and release pathways 60/100

Performance & recovery (13)

Selective GH Release 85/100· 3 srcSelective Growth Hormone Release 90/100Selective GH Release Without Hormonal Side Effects 90/100Increases fat-free mass 90/100Selective GH Secretion 90/100GHRPs stimulate GH release via GHSR-1a 90/100MK-677 maintains GH and IGF-I elevation under continuous administration 90/100Selective GH Secretagogue 90/100Selective Growth Hormone Stimulation 85/100Selective GH secretion via GHS-R1a agonism 85/100Growth hormone secretagogue 72/100IGF-1 LR3 Sustained Anabolic Signalling 72/100Synergistic GH Release via GHRH and GHRP Combinations 72/100

Weight management (10)

Visceral Fat Reduction 85/100· 2 srcAppetite stimulation 90/100Decrease in fat mass while maintaining lean mass 85/100Increased Lean Body Mass 80/100Reduced Adipose Tissue 80/100Promotes lipolysis and reduces adipose tissue 80/100Minimal Appetite Stimulation 80/100Body Composition Improvements 75/100Accelerates fat loss and improves body composition over 6-8 weeks 60/100Enhanced lipolysis and fat metabolism 60/100

Gastrointestinal & gut (5)

Gastrointestinal Motility / Prokinetic Effects 85/100Gastrointestinal Motility Acceleration 85/100Heals gut issues 80/100Potential Prokinetic Effect 80/100Effective for Postoperative Ileus with Excellent Tolerability 75/100

Neuroprotection & cognitive (4)

Neuroprotective benefits 70/100Reduces anxiety without sedation 70/100Improves sleep 70/100Reduces anxiety comparable to benzodiazepines 70/100

Musculoskeletal (3)

Supports bone healing 85/100· 2 srcMinimal cortisol, prolactin, and aldosterone elevation at GH-active doses 90/100Speeds muscle recovery 75/100

Sleep & circadian (2)

Improves sleep 80/100Restores nocturnal melatonin production 65/100

Tissue & wound healing (2)

Complementary Tissue Repair Mechanisms with BPC-157 and TB-500 72/100Boosts collagen production 60/100

Other Benefits (8)

Stimulates growth hormone release 76/100· 3 srcSelective GHS-R agonism drives pulsatile GH secretion from the pituitarySelective GH release without cortisol/ACTH elevation 90/100Sustained dosing produces cumulative pituitary-level changes in somatotroph cells 85/100Synergistic GH Release with GHRH Analogs 85/100Sustained GHRHR Stimulation via CJC-1295 with DAC Albumin Binding 72/100Supports liver health 95/100Favorable Safety and Tolerability Profile 85/100Improves Lipid Profiles and Reduces Visceral Fat 70/100

How People Use It

Under the skin

  • 2.3 nmol/kg

For research purposes only. Not medical advice. Talk to a doctor before use.

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Technical Details & Research (click to expand)

Amino Acid Sequence

Ipamorelin9 residues
A
H
D
N
D
P
L
N
H
Hydrophobic Acidic Basic Polar Aromatic

Mechanism of Action

Ipamorelin is a synthetic pentapeptide, a third-generation growth hormone releasing peptide (GHRP) and selective agonist of the ghrelin/growth-hormone secretagogue receptor (GHS-R) on pituitary somatotropes. It stimulates pulsatile GH release while having minimal effect on ACTH, cortisol, or prolactin - the first relatively selective GH secretagogue. It is not FDA-approved.

Known Side Effects

All Dosing Protocols

Research Dose (Swine) — SubQ 95/100

Research Citations (90)

  • Ipamorelin, the first selective growth hormone secretagogue.

    AnimalStudy1998 Key study 84/100
    Source

  • Ipamorelin for post-operative ileus (NCT00672074)

    Registry2014 78/100
    Source

  • Clinical Drug Investigation (2008)

    90/100
    Source

  • European Journal of Endocrinology (1998)

    90/100
    Source

  • Growth Hormone & IGF Research (1999)

    90/100
    Source

  • Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics

    90/100
    Source

  • The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats

    90/100
    Source

  • The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats

    90/100
    Source

  • Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats

    90/100
    Source

  • Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus

    90/100
    Source

  • Ghrelin Stimulates Endothelial Cells Angiogenesis through Extracellular Regulated Protein Kinases (ERK) Signaling Pathway

    90/100
    Source

  • Ghrelin up-regulates cartilage-specific genes via the ERK/STAT3 pathway in chondrocytes

    90/100
    Source

  • Enhancement of the chondrogenic differentiation of mesenchymal stem cells and cartilage repair by ghrelin

    90/100
    Source

  • Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children

    90/100
    Source

  • Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone

    90/100
    Source

History & Milestones

Key moments in Ipamorelin’s research and regulatory timeline — sourced and dated.

  1. Ipamorelin, the first selective growth hormone secretagoguePublicationJan 1, 1998
    84/100↗ source

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