Home / Peptides

CJC-1295

Also called: CJC-1295 with DAC, Modified GRF 1-29 (no DAC)

By The Health Stacks Research TeamUpdated July 28, 2026

CJC-1295 is a chemical made in labs that acts like a tiny messenger in the body. It belongs to a group called peptides, which are small chains of building blocks. Scientists and researchers are the main people who use this chemical. They buy it to study it in test tubes or special lab settings. It is not a vitamin or a medicine you can buy at a regular store. The law says it is only for research, so people cannot use it as a drug.

It comes as a dry white powder that needs to be handled very carefully by experts.This chemical is known for telling the body to make more of a specific hormone. That hormone is called growth hormone, which helps kids grow and keeps muscles strong in adults. By using CJC-1295, researchers try to see if the body can keep making this hormone for a long time. The chemical sticks to certain spots in the body to send its signal. This is why many studies look at how it affects muscles, fat, and sleep. The goal is to understand how the body controls growth and energy over time.There are still many things we do not know about CJC-1295.

Most of the tests so far have been done on animals or in small groups of people. We do not have enough proof to say it is safe for humans to use as a treatment. Because of this, it is not allowed for human use. It can only be used in labs to follow the rules. Scientists are still trying to learn if it works well or if it causes bad reactions. It is important to remember that this is not a safe product for personal use yet.

Research-stageEarly-stage — studied in cell or animal models, not yet tested in humans. Medium confidence40–59 — backed by moderate-quality sources. Worth a closer look at the individual citations.
Where to Source CJC-1295
Tested purity COA available Fast shipping

What CJC-1295 Helps With

The benefits people report — backed by research.

Reproductive & hormonal (40)

Sustained GH elevation 80/100· 10 src2-10x mean GH concentrations over days after dosing (with DAC)IGF-1 elevation 85/100· 3 srcSustained IGF-1 elevation 80/100· 3 srcDose-dependent IGF-1 increases lasting days (single dose) to weeks (repeat dosing)Preservation of Pulsatile GH Secretion 90/100· 2 srcNormalized growth in GHRH knockout mice 75/100· 2 srcProlonged stimulation of growth hormone and IGF-1 secretion by CJC-1295 90/100Increases trough GH levels while preserving natural pulsatile secretion 90/100Sexual arousal and desire modulation via CNS 90/100Diagnosis of adult growth hormone deficiency 90/100Treatment of acromegaly 90/100Increases Growth Hormone and IGF-I levels 90/100Sustained elevation of Growth Hormone and IGF-1 85/100GHRH analogs increase GH pulse mass and IGF-1 85/100Preservation of natural pulsatile GH secretion 85/100Preserved hypothalamic-pituitary feedback loop with secretagogues 85/1007.5-fold increase in basal GH levels 85/100Pulsatile Growth Hormone Release 85/100Preserved pulsatile GH secretion 85/100Increases Growth Hormone and IGF-1 levels 85/100Selective GH release 85/100Preserved Pulsatile Secretion 85/100Acute, high-amplitude GH pulses 85/100Pulsatile GH Release Pattern 85/100Synergistic GH Release 85/100Elevated IGF-1 Levels 85/100High receptor selectivity with minimal endocrine noise 80/100Selective GH Release without Cortisol, Prolactin, or ACTH Elevation 80/100Mimics Natural GH Rhythm 80/100Preservation of Natural Pulsatile GH Rhythm 80/100Normalized growth in GHRH-deficient mice 80/100Sustained basal increase in GH/IGF-1 80/100Preserves physiological pulsatile GH secretion 80/100Dual pathway growth hormone secretagogue model 72/100Minimal Cortisol and Prolactin Elevation 72/100Promotion of Ovulation 70/100Stimulates fat loss / Normalizes prolactin levels 70/100Selective GH release with minimal cortisol or prolactin impact 70/100Synergistic GH elevation when combined with GHRPs 65/100Stimulates GH release in a pulsatile pattern 65/100Physiological pulsatile GH stimulation 60/100

Performance & recovery (35)

Cleaner GH elevation with fewer side effects 60/100· 7 srcSynergistic Growth Hormone Release 72/100· 3 src2-10 fold GH increases and 1.5-3 fold IGF-1 elevation 90/100· 2 srcDose-proportional GH and IGF-1 elevation 85/100· 2 srcConvenience Over No-DAC 80/100· 2 srcConvenience of less-frequent dosing 60/100· 2 srcSustained dose-dependent GH and IGF-1 elevation 90/100Prolonged GH and IGF-1 elevation 90/100Sustained GH stimulation and IGF-1 elevation 90/100Increased GH and IGF-1 secretion 90/100Enhanced GH and IGF-1 Levels 85/100Sustained elevation of GH and IGF-1 85/100Acute pulsatile GH secretion 85/100Increased GH and IGF-1 Levels 85/100Elevates GH pulse mass and IGF-1 85/100Prolonged stimulation of GH and IGF-1 85/100Selective growth hormone secretagogue action 85/100Sustained IGF-1 elevation 85/100Growth Hormone Release 85/100Sustained elevation of GH and IGF-1 levels 85/100Increased Growth Hormone Release 85/100Increases GH and IGF-1 levels 85/100Enhances exercise capacity and stress response 80/100Extended half-life and sustained GHRH receptor stimulation 80/100CJC-1295 with DAC provides sustained IGF-1 elevation via albumin binding 80/100Lean Tissue Accretion 80/100Growth hormone secretagogue 70/100Synergistic GH release 65/100Stimulation of endogenous growth hormone secretion 65/100Elevation of IGF-1 levels 65/100Growth hormone secretagogue activity 65/100Speeds recovery 60/100Synergistic GH release when combined with Ipamorelin 60/100Significant GH pulses 60/1005-10x synergistic GH pulse amplification when stacked with a GHRP 60/100

Weight management (18)

Visceral fat reduction 90/100· 2 srcIncreased lean body mass 85/100· 2 srcIncreased lean body mass and favorable body composition shifts 85/100· 2 srcImproved body composition 85/100· 2 srcReduces visceral adipose tissue 90/100Visceral adipose tissue reduction 90/100Visceral Adiposity Reduction 90/100Supports weight loss 90/100Reduction in total body fat and visceral adipose tissue 85/100Reduced Body Fat 85/100Increased Lean Mass / Reduced Fat Mass 80/100Increased lean body mass and reduced fat mass 80/100Favorable Body Composition Shifts 80/100Lipolytic effects and visceral fat reduction 75/100Speeds recovery 72/100Enhanced fat metabolism and body composition 70/100Promotion of body composition changes 65/100Reduces abdominal and visceral fat 60/100

Glycemic & metabolic (5)

Extended half-life of 5-8 days via albumin binding 90/100· 2 srcExtended half-life via albumin binding 90/100Helps regulate blood sugar 85/100Extended half-life via DAC binding to albumin 85/100Raises IGF-1 and modulates fasting glucose 60/100

Musculoskeletal (5)

Speeds muscle recovery 85/100· 7 srcSyringes are permitted in carry-on luggage when accompanied by injectable medication 90/100Increased GH Secretion 85/100Restores LH pulsatility and increases testosterone 80/100Supports bone healing 80/100

Gastrointestinal & gut (4)

Heals gut issues 95/100Improved Bioavailability 85/100Treatment of diabetic gastroparesis 75/100Boosts blood flow to injuries 72/100

Cardiovascular & vascular (4)

Cardioprotective effects 85/100Cardioprotective 80/100Favorable lipid profile changes 75/100Cardioprotective effects independent of GH 75/100

Tissue & wound healing (4)

Heals wounds faster 80/100Boosts blood flow to injuries 80/100Boosts collagen production 70/100Tissue Repair and Healing 65/100

Antimicrobial & antiviral (2)

Reduction of HIV-associated Lipodystrophy 90/100Treatment of HIV-associated lipodystrophy 90/100

Anti-inflammatory (2)

Helps regulate blood sugar 85/100Reduces adipose inflammatory tone 80/100

Sleep & circadian (2)

Improves sleep 85/100· 2 srcPulsatile GH release mimicking natural circadian rhythms 80/100

Immune modulation (2)

Strengthens immunity 85/100Reduced Immunogenicity 70/100

Other Benefits (13)

Sustained IGF-1 and GH Elevation 95/100· 2 srcSustained IGF-1 elevation for up to 28 days after multiple doses 90/100· 2 srcSustained GH and IGF-1 elevation 90/100· 2 srcSerum protein profile changes consistent with improved metabolic health 85/100Stimulation of GH release via GHRH receptor 85/100Stimulation of GH release via Ghrelin receptor 85/100Synergistic GH Release via GHRH and GHS-R1a Co-Activation 80/100Sustained GH Elevation 80/100Supports brain health 85/100Renal protective properties 85/100Boosts energy 80/100Reduced abdominal fat and improved fat oxidation 60/100Improves skin health 60/100
CJC-1295 — strength

How People Use It

Under the skin

  • Once-weekly CJC-1295 DAC combined with daily or thrice-weekly ipamorelin

For research purposes only. Not medical advice. Talk to a doctor before use.

Get CJC-1295 for Your Research

Compare research-grade suppliers with third-party COAs and published purity data. For in-vitro and laboratory research use only — not for human consumption, diagnosis, or treatment.

Find CJC-1295 Research Suppliers
Tested purity COA available Fast shipping
Technical Details & Research (click to expand)

Mechanism of Action

CJC-1295 is a synthetic analog of growth hormone releasing hormone (GHRH). The Drug Affinity Complex (DAC) binds serum albumin, extending half-life to roughly a week and producing sustained, dose-dependent increases in GH (2-10x) and IGF-1 lasting days to weeks. It is not FDA-approved.

Known Side Effects

All Dosing Protocols

Macimorelin — SubQ 90/100

Research Citations (98)

  • Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.

    RCT2006 Key study 86/100
    Source

  • Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.

    AnimalStudy2009 80/100
    Source

  • Once-daily administration of CJC-1295

    AnimalStudy2006 78/100
    Source

  • Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse

    2006 90/100
    Source

  • Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295

    2006 90/100
    Source

  • Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295

    2006 90/100
    Source

  • Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats

    2005 90/100
    Source

  • A Single-Dose, Dose-Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of CJC-1295

    95/100
    Source

  • Effects of Tesamorelin on Visceral Fat and Hepatic Fat Content in HIV-Infected Patients with Abdominal Fat Accumulation

    95/100
    Source

  • The Effect of Tesamorelin on Visceral Adipose Tissue and Liver Fat in HIV-Infected Patients

    95/100
    Source

  • Effects of Tesamorelin on Cognitive Function in Healthy Older Adults

    95/100
    Source

  • Effects of a novel peptide with GH-releasing properties in normal adults and patients with GHD

    90/100
    Source

  • Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults

    90/100
    Source

  • Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans

    90/100
    Source

  • Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation

    90/100
    Source

History & Milestones

Key moments in CJC-1295’s research and regulatory timeline — sourced and dated.

  1. Activation of the GH/IGF-1 axis by CJC-1295PublicationJan 1, 2009
    80/100↗ source
  2. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I by CJC-1295PublicationJan 1, 2006
    86/100↗ source
  3. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mousePublicationJan 1, 2006
    90/100↗ source
  4. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295PublicationJan 1, 2006
    90/100↗ source
  5. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295PublicationJan 1, 2006
    90/100↗ source
  6. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in ratsPublicationJan 1, 2005
    90/100↗ source

Free: The Peptide Stack Cheat-Sheet

The most-used peptide combinations, dosing at a glance, and what the research says — one page, one email.

No spam. Unsubscribe anytime.

Related on The Health Stacks

Explore by goal

Growth Hormone Secretagogues

Related peptides

IpamorelinTesamorelin

Compare

CJC-1295 vs Ipamorelin