Sermorelin vs Ipamorelin
A GHRH analog and a ghrelin-mimetic aimed at the same growth-hormone pulse — commonly stacked, frequently compared. Here's a neutral, sourced side-by-side — no hype, every claim links to its evidence.
Sermorelin
ApprovedAlso: GRF 1-29, GHRH 1-29
Sermorelin is a substance that tells your body to make more of its own growth hormone. Growth hormone is a natural body chemical that helps with healing, muscle, and energy.
Ipamorelin
ResearchAlso: GHRP, Ipamorelin and CJC-1295
Ipamorelin is a man-made peptide, which is a tiny chain of building blocks called amino acids. It is a copy of a natural body chemical called ghrelin, which is sometimes called the hunger hormone.
At a Glance
| Sermorelin | Ipamorelin | |
|---|---|---|
| Research status | Approved | Preclinical |
| Highest-tier evidence | Peer-reviewed study | Peer-reviewed study |
| Research citations | 10 | 8 |
| Dosing routes | SubQ | — |
| Receptor targets | GHRH receptor | GHS-R (ghrelin receptor) |
| Half-life | — | — |
| Known side effects | 46 | 9 |
Research Areas
Top preclinical research areas — cited studies for each.
Sermorelin
- Reliable GH stimulation testing
- Stimulates endogenous GH
Ipamorelin
- Stimulates GH release
- Selective (minimal cortisol)
How People Use It
Reported routines — research only, not medical advice.
Sermorelin
- SubQ — 0.2 - 0.3 mg once daily at bedtime
- SubQ — 500/500 mcg increasing to 1,000/1,000 mcg
- SubQ — Sermorelin 200 to 300 mcg plus ipamorelin 200 to 300 mcg
Ipamorelin
- — 100–250 mcg once daily SC (research: 100–300 mcg 2–3×/day)
The Evidence
Key studies — click through to verify each on PubMed.
Sermorelin
10 sourced studies
- Source
Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.
Review2008 Key study 84/100Rated 84/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitro.
2009 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release.
1995 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
PubChem - Compound - Sermorelin
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
Ipamorelin
8 sourced studies
- Source
Ipamorelin, the first selective growth hormone secretagogue.
AnimalStudy1998 Key study 84/100Rated 84/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Ipamorelin for post-operative ileus (NCT00672074)
Registry2014 78/100Rated 78/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers.
1999 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats.
1999 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
Decision Guide
How to Choose
Neither is a “winner” — they suit different goals. Compare the documented benefits and evidence above against what you’re actually trying to achieve, note the research status (approved vs research-stage), and read each full guide before deciding. Many people also stack peptides rather than pick one.
Source Sermorelin
Shop SermorelinSource Ipamorelin