GHRP-2
Shop GHRP-2Also called: KP-102, Pralmorelin, Pralmorelin Hydrochloride
GHRP-2 is a man-made chain of tiny building blocks called amino acids. It is a lab-made copy of a natural body signal called ghrelin. Ghrelin is the hormone that makes you feel hungry. GHRP-2 tells a part of the brain to release more growth hormone. Growth hormone is a body chemical that helps with growing, healing, and burning fat.
Scientists have studied GHRP-2 mostly in labs and in animal tests. It works by fitting into the same switches on cells that hunger hormones use. When it turns those switches on, the body releases a burst of growth hormone. Some people in fitness and bodybuilding groups have used it, hoping it would help build muscle or burn fat. Some also said it made them feel very hungry.
There are big problems to know about. GHRP-2 is not an approved medicine anywhere. The US food and drug agency put it in a group of substances that may have serious safety risks, including reported deaths. It is not legal for pharmacies to mix it into medicines. Products sold online are not checked for purity, so you cannot be sure what is in them. Scientists still do not know if it is safe for people, so doctors warn against using it.
Benefits
What GHRP-2 Helps With
The main themes across 23 research studies, in plain language.
Musculoskeletal
Muscle growth & performance
55/100Rated 55/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 18 underlying claimsStudies indicate potential benefits for increasing muscle mass, strength, and exercise recovery through anabolic pathways.
Bone density & skeletal health
80/100Rated 80/100Source typePeer-reviewed studyIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 5 underlying claimsResearch points to potential improvements in bone density and skeletal growth, particularly in deficient states.
Reproductive & hormonal
Growth hormone release
65/100Rated 65/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 28 underlying claimsResearch suggests GHRP-2 acts as a potent stimulator of growth hormone secretion, often used in diagnostic settings.
Synergy with GHRH analogs
60/100Rated 60/100Source typeSpecialist communityIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 6 underlying claimsEvidence indicates that combining this peptide with GHRH analogs creates a synergistic effect, amplifying growth hormone release.
Hormonal profile & cortisol
60/100Rated 60/100Source typeSpecialist communityIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 5 underlying claimsStudies suggest a favorable secondary hormone profile compared to similar peptides, with moderate effects on cortisol.
Tissue repair & skin health
40/100Rated 40/100Source typeVendor / seller pageIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 7 underlying claimsResearch suggests the peptide may accelerate wound healing and improve skin quality through collagen synthesis.
Anti-inflammatory & organ protection
50/100Rated 50/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 7 underlying claimsStudies demonstrate anti-inflammatory actions that may protect organs like the liver and the immune system during stress.
Cellular defense & oxidative stress
60/100Rated 60/100Source typeSpecialist communityIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 6 underlying claimsFindings suggest the compound supports cellular defense mechanisms by suppressing oxidative stress and inhibiting cell death.
Appetite & weight regulation
40/100Rated 40/100Source typeVendor / seller pageIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 13 underlying claimsResearch points to appetite-stimulating effects that may increase caloric intake and support weight gain in specific conditions.
Fat metabolism & body composition
40/100Rated 40/100Source typeVendor / seller pageIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 9 underlying claimsFindings imply a role in promoting fat loss and improving overall body composition by reducing fat mass.
Cardiovascular protection
50/100Rated 50/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 9 underlying claimsAnimal studies indicate potential cardioprotective properties, including the reduction of heart fibrosis and oxidative stress.
Neuroprotection & cognition
72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 7 underlying claimsPreliminary research suggests neuroprotective effects that may improve memory and reduce markers of brain inflammation.
Sleep quality & architecture
50/100Rated 50/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 9 underlying claimsEvidence suggests the compound may enhance sleep depth and quality, particularly slow-wave sleep stages.
Energy & mitochondrial support
30/100Rated 30/100Source typeVendor / seller pageIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 underlying claimsResearch suggests the peptide may help increase overall energy levels and combat fatigue.
Injury recovery & joint comfort
50/100Rated 50/100Source typeSpecialist communityIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 underlying claimsAnecdotal and preliminary evidence suggest it may accelerate recovery from injuries and improve joint comfort.
Research examples
- Accelerates recovery from injuries
- Improved recovery from exercise and injury
- Accelerated wound healing, joint comfort, and skin/hair quality
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How People Use It
1 reported routine — each line links to the source it came from.
From published sources
Routines as reported in peer-reviewed papers, clinical guidance, or vetted media — each linked to the source it came from.
SubQ
- Not specified (determined by professional) 60/100Rated 60/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source
mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.
Safety
Known Side Effects
Adverse effects reported in the research and by community use.
- Injection site reactions (painMild 60/100Rated 60/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ synapse.patsnap.com
- Transient headachesMild 60/100Rated 60/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ synapse.patsnap.com
- Water retentionSevereReported in 5 sources 60/100Rated 60/100Source typeEstablished referenceIndependent sources5Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ synapse.patsnap.com↗ thepeptidecatalog.com↗ thepeptidecatalog.com↗ thepeptidecatalog.com+1
- Increased risk of carpal tunnel syndromeSevere 60/100Rated 60/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ synapse.patsnap.com
- Hyperglycemia or impaired glucose toleranceSevere 60/100Rated 60/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ synapse.patsnap.com
- RednessMild 60/100Rated 60/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ synapse.patsnap.com
- DizzinessMild 60/100Rated 60/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ synapse.patsnap.com
- or nauseaMild 60/100Rated 60/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ synapse.patsnap.com
- EdemaSevere 60/100Rated 60/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ synapse.patsnap.com
- swelling)Mild 60/100Rated 60/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ synapse.patsnap.com
- Flushing and warmth at the injection site or faceMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
- Transient drowsiness or sleepinessMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
- Mild water retention and peripheral edemaMildReported in 2 sources 60/100Rated 60/100Source typeSpecialist communityIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org↗ peptidepedia.org
- Increased gastrointestinal motilityMildReported in 2 sources 60/100Rated 60/100Source typeSpecialist communityIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org↗ peptidepedia.org
- Elevations in cortisol and ACTHModerate 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
- Mild prolactin elevationModerate 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
- Numbness or tingling in extremitiesMildReported in 2 sources 60/100Rated 60/100Source typeSpecialist communityIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org↗ peptidepedia.org
- Joint stiffnessMildReported in 2 sources 60/100Rated 60/100Source typeSpecialist communityIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org↗ peptidepedia.org
- Lightheadedness post-injectionMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
- Moderate appetite stimulationMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
- Flushing and warmthMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
- Transient drowsinessMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
- Intense appetite stimulationMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
- Transient flushing and dizzinessMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
- Moderate appetite increaseMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
- Mild water retentionMildReported in 3 sources 60/100Rated 60/100Source typeSpecialist communityIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org↗ holisticnootropics.com↗ peptide-db.com
- LightheadednessMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
- Increased hunger and gastric emptying (GHRP-2/GHRP-6)Mild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ excelmale.com
- Elevated prolactin and cortisol (GHRP-2/GHRP-6)Moderate 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ excelmale.com
Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.
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Technical Details (sequence & mechanism — click to expand)
Mechanism of Action
GHRP-2 (pralmorelin) is a synthetic hexapeptide agonist of the ghrelin receptor (GHSR-1a) on pituitary somatotropes, stimulating potent endogenous GH release (peak GH 30-100 ng/mL). It also increases appetite, mimicking ghrelin. Used as a diagnostic for GH deficiency; not approved therapeutically in the US.
Evidence
Research Citations (6)
Every claim above traces back to a source you can check — here are 6 of them.
- Source
Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men
Review2010 Key study 82/100Rated 82/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Pralmorelin: GHRP 2, GPA 748, growth hormone-releasing peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN.
Review2004 80/100Rated 80/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
General pharmacology of KP-102 (GHRP-2), a potent growth hormone-releasing peptide.
2004 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
PubChem - Compound - Pralmorelin
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
ACTH releasing activity of KP-102 (GHRP-2) in rats is mediated mainly by release of CRF
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Determinants of GH-releasing hormone and GH-releasing peptide synergy in men
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
Timeline
History & Milestones
Key moments in GHRP-2’s research and regulatory timeline — sourced and dated.
News
Latest on GHRP-2
Dated, sourced reporting that mentions GHRP-2.
Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks
FDA's running list of bulk drug substances that present significant safety risks in compounding names GHRP-2, GHRP-6, ipamorelin acetate, CJC-1295 and AOD-9604. GHRP-2 and GHRP-6 were added to the 503B risk list on September 29, 2023 over immunogenicity concerns, and FDA notes serious adverse events for CJC-1295 (increased heart rate, systemic vasodilatory reactions). The list confirms these peptides are treated by FDA as unsafe-for-compounding substances.
Tailor Made Compounding LLC
FDA warned Tailor Made Compounding LLC (Nicholasville, KY) after a 2018 inspection found it compounded drug products with bulk substances ineligible for 503A exemptions. The letter explicitly lists the compounded substances: Follistatin, GHRP-2, GHRP-6, AOD 9604, BPC 157, Bremelanotide (PT-141), Cerebrolysin, DSIP, Epitalon, GHK-Cu, Ipamorelin, LL-37, Melanotan II, Selank, Semax, and CJC 1295, among others. The firm was cited for insanitary aseptic processing (adulteration), unapproved new drugs, and misbranding, and removed GHRP-2 and GHRP-6 from its formulary in response.
Wondering how GHRP-2 pricing compares across suppliers? Our original market data shows the full picture.
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