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TB-500

Also called: Thymosin beta-4

By The Health Stacks Research TeamUpdated July 28, 2026

TB-500 is a man-made substance that copies a small part of a natural protein in the body called Thymosin Beta-4. It is mostly used by researchers and people who want to heal faster. It comes as a white powder that is frozen dry to keep it stable.

This product is sold only for lab research and is not meant to be eaten or used as medicine.This substance is famous for helping the body fix injuries. It works by helping cells move to the right spot to repair damage, like cuts or muscle tears. It also helps build new blood vessels, which brings more blood to hurt areas.

This is why many people look at it for healing wounds and recovering from tough workouts.We do not know everything about how this works in humans yet. Most of the proof comes from studies on animals, not people. Because it is not approved for eating, it can be risky to use. You should be very careful and know that it is only for studying in a lab, not for personal use.

Research-stageEarly-stage — studied in cell or animal models, not yet tested in humans. Medium confidence40–59 — backed by moderate-quality sources. Worth a closer look at the individual citations.
Where to Source TB-500
Tested purity COA available Fast shipping

Regulatory status

On July 23, 2026, PCAC voted 8–6–1 to recommend adding TB-500 to the Section 503A Bulks List. The recommendation is non-binding; FDA rulemaking must follow before any change in legal status, typically 12–24 months. TB-500 is not on the 503A Bulks List and remains an unapproved new drug that 503A pharmacies cannot lawfully compound pending final FDA action.

Status as of July 27, 2026↗ source

What TB-500 Helps With

The benefits people report — backed by research.

Tissue & wound healing (25)

Heals wounds faster 90/100· 4 srcDrives keratinocyte/fibroblast migration and wound closure in preclinical modelsTissue repair and regeneration 60/100· 4 srcReduces inflammation 88/100· 2 srcCorneal repair 80/100· 2 srcCorneal and Ocular Healing 80/100· 2 srcConnective Tissue Repair / Reduced Scarring 85/100Cytoskeletal regulation and tissue remodeling 85/100Reduces fibrosis and scar tissue formation 85/100Boosts blood flow to injuries 85/100Promotes cell migration and tissue repair via actin sequestration 85/100Reduces scar formation and fibrosis 85/100Reduces scar size and improves cardiac function post-myocardial infarction 85/100Boosts collagen production 85/100Speeds up healing 85/100Reduction of scar formation 85/100Cardiac tissue repair and survival 85/100Accelerates closure rates in chronic venous ulcers 80/100Stem cell mobilization and differentiation 80/100Corneal epithelial healing 75/100Reduced Fibrosis/Scarring 75/100Promotes cellular migration and tissue remodeling via actin sequestration 72/100Reduces excessive scar tissue formation 72/100Repairs tendons and ligaments 70/100Cytoskeletal modulation and tissue remodeling by SDKP 70/100Musculoskeletal tissue repair 60/100

Cardiovascular & vascular (15)

Boosts blood flow to injuries 95/100· 4 srcUpregulates VEGF and bFGF, supporting endothelial migration and new vessel formationCardiac repair 90/100· 2 srcCardiac Function Improvement 90/100Enhanced myocyte survival and improved cardiac function following coronary artery ligation 90/100Cardioprotection and reduced infarct size 85/100Promotes cardiac repair and reduces infarct size 85/100Inhibits myocardial cell death and activates endogenous cardiac progenitors 85/100Reactivates adult epicardial progenitor cells for cardiac repair 85/100Treatment of acute decompensated heart failure 85/100Speeds recovery 85/100Enhances cardiac cell survival and repair post-myocardial infarction 80/100Improves cardiac function after ischemic injury 80/100Cardioprotective properties / reduces infarct size 80/100Cardioprotective properties 70/100Nitric oxide pathway modulation 70/100

Gastrointestinal & gut (6)

Improved oral bioavailability via structural modification 85/100Reduction of intestinal permeability 85/100Intestinal growth and absorption 85/100Protects your cells 85/100Improved oral bioavailability of TB-500 via SDKP fragment 75/100Enhanced oral bioavailability of BPC-157 via Arginate salt form 75/100

Cytoprotection / cellular defense (3)

G-actin sequestration and cytoskeletal regulation 90/100Actin sequestration 85/100Protects your cells 75/100

Reproductive & hormonal (3)

Regulation of reproductive function 85/100Reduction of postpartum blood loss 85/100Suppression of sex hormone production 85/100

Neuroprotection & cognitive (3)

Neuroprotection 75/100· 6 srcSupports brain health 85/100Speeds recovery 80/100

Skin, hair & cosmetic (3)

Hair Growth 75/100Hair Follicle Activation 75/100Improves skin health 75/100

Musculoskeletal (2)

Repairs tendons and ligaments 85/100· 2 srcSpeeds muscle recovery 85/100

Performance & recovery (2)

Growth hormone release 85/100Speeds recovery 80/100

Anti-aging & longevity (2)

Cellular metabolism and DNA repair 85/100Mobilizes epicardial and satellite stem cells 72/100

Antioxidant / oxidative stress (2)

Antioxidant effects 80/100Reduces reactive oxygen species -mediated damage in renal and cardiac injury models 65/100

Other Benefits (10)

Reduces inflammation 85/100· 5 srcModulates inflammatory signaling at injury sites in animal modelsTreatment of Dry Eye 80/100Supports weight loss 85/100Mitochondrial bioenergetics optimization 85/100Inhibition of tumor growth 85/100Antimicrobial activity 85/100Protects against renal disease progression 80/100Supports liver health 80/100Stem cell mobilization 75/100Helps regulate blood sugar 75/100
TB-500 — recovery

How People Use It

Under the skin

  • Lyophilized powder reconstituted with bacteriostatic water

For research purposes only. Not medical advice. Talk to a doctor before use.

Get TB-500 for Your Research

Compare research-grade suppliers with third-party COAs and published purity data. For in-vitro and laboratory research use only — not for human consumption, diagnosis, or treatment.

Find TB-500 Research Suppliers
Tested purity COA available Fast shipping
Technical Details & Research (click to expand)

Amino Acid Sequence

TB-50043 residues
S
D
K
P
D
M
A
E
I
E
K
F
D
K
S
K
L
K
K
T
E
T
Q
E
K
N
P
L
P
S
K
E
T
I
E
Q
E
K
Q
A
G
E
S
Hydrophobic Acidic Basic Polar Aromatic

Mechanism of Action

TB-500 is a synthetic version of thymosin beta-4, an endogenous 43-amino-acid peptide that sequesters G-actin to drive cytoskeletal remodeling and directed cell migration. It promotes keratinocyte, fibroblast, and endothelial migration, upregulates VEGF/bFGF to stimulate angiogenesis, and modulates inflammation. Evidence is predominantly preclinical with some early-phase clinical study.

Known Side Effects

All Dosing Protocols

RGN-259 (Clinical) — SubQ 90/100

Research Citations (79)

  • Thymosin beta4 accelerates wound healing.

    AnimalStudy1999 Key study 86/100
    Source

  • Progress on the Function and Application of Thymosin beta4

    Review2021 80/100
    Source

  • Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State-New Directions in Anti-Aging Regenerative Therapies

    Review2021 78/100
    Source

  • Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications.

    95/100
    Source

  • Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma

    95/100
    Source

  • Structural basis of actin sequestration by thymosin-beta4: implications for WH2 proteins.

    95/100
    Source

  • Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse.

    95/100
    Source

  • Thymosin beta4 enhances repair by organizing connective tissue and preventing the appearance of myofibroblasts.

    95/100
    Source

  • Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.

    95/100
    Source

  • Thymosin β4: a multi-functional regenerative peptide

    95/100
    Source

  • Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

    95/100
    Source

  • Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization

    95/100
    Source

  • Biological activities of thymosin beta4 defined by active sites in short peptide sequences

    95/100
    Source

  • Thymosin beta 4 promotes angiogenesis, wound healing, and hair follicle development

    95/100
    Source

  • Treatment of traumatic brain injury with thymosin β4 in rats

    95/100
    Source

History & Milestones

Key moments in TB-500’s research and regulatory timeline — sourced and dated.

  1. Thymosin beta4 accelerates wound healingPublicationJan 1, 1999
    86/100↗ source

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