FOXO4-DRI

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Also called: FOXO4 Compound, FOXO4-DRI UK, FOXO4 peptide

By The Health Stacks Research TeamUpdated September 21, 2026

FOXO4-DRI is a lab-made peptide, which is a tiny chain of building blocks called amino acids. It was designed by scientists to study aging. It belongs to a group of compounds sometimes called longevity peptides. Researchers, not doctors, are the main people working with it.

In lab studies with old mice, this peptide seemed to help clear out worn-out cells that build up as animals age. Those tired cells can make tissues work poorly. The peptide works by interfering with a handshake between two proteins inside cells, which may push old damaged cells to remove themselves. In the mouse studies, researchers saw better fitness and some signs of healthier fur and kidneys.

Very little is known about how it acts in people. There are no finished human studies, so its safety and effects in humans are unknown. It is not an approved medicine anywhere. Anyone reading about it should know the evidence comes from animal work only, and handling it carries real risks. (Word on scope: the crawled pages only discuss FOXO4-DRI briefly — as a listing in longevity research guides and as a vendor product — so many practical details remain undocumented here.)

Research-stageEarly-stage — evidence so far is mostly cell, animal, or preliminary human studies. Not an approved medicine. Verified confidence80–100 — backed by strong, well-corroborated sources (peer-reviewed research, clinical guidelines). Our highest confidence tier.

Benefits

What FOXO4-DRI Helps With

The benefits people report — backed by research.

Anti-aging & longevity (3)

Suppresses aortic aging in naturally aged and progeroid mice 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Disrupts p53-FOXO4 interaction to promote nuclear exclusion of p53 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Disrupts p53-FOXO4 interaction to promote p53 nuclear exclusion 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

More reported benefits (5)

Selective removal of senescent cells in expanded chondrocytes 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Neutralizes doxorubicin-induced chemotoxicity 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Restores fitness, fur density, and renal function in aged mice 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduces G0/G1 phase cell cycle arrest in senescent cells 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Tissue repair 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

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Evidence

Research Citations (7)

Every claim above traces back to a source you can check — here are 7 of them.

  • PubChem - Compound - Foxo4-dri

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.

    2020 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • FOXO4-D-Retro-Inverso targets extracellular matrix production in fibroblasts and ameliorates bleomycin-induced pulmonary fibrosis in mice.

    2023 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells.

    2024 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation.

    2025 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.

    2025 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • PubChem - Compound - FOXO4-DRI acetate

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

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