NAD+
Shop NAD+Also called: Nicotinamide Adenine Dinucleotide, NAD
NAD+ is a tiny molecule that every living thing needs to stay alive. It is not really a peptide, but it is sold in powder form alongside peptides for lab studies. Scientists and lab researchers buy it to study how cells make energy. It is not a medicine and is not approved by the FDA for people or animals.
NAD+ helps tiny parts inside your cells turn food into energy. It also helps cells fix damage and stay healthy as they age. Because of this, researchers study it a lot when looking at aging and cell health. In lab tests, keeping NAD+ levels up seems to help cells work better.
Most of what we know comes from lab and animal studies, not from careful human trials. Scientists are still learning how well NAD+ works in people and if it is safe. The powder sold online is for research only and should not be eaten or injected by people. It must be kept cold and away from light so it does not spoil.
Benefits
What NAD+ Helps With
The main themes across 20 research studies, in plain language.
Energy & mitochondrial
Cellular energy & vitality
40/100Rated 40/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 7 underlying claimsResearch suggests NAD+ plays a central role in cellular energy production and may help reduce feelings of fatigue.
Mitochondrial function support
72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 5 underlying claimsStudies indicate that NAD+ is essential for mitochondrial health and may improve muscle performance in mitochondrial disorders.
Cellular defense & repair
90/100Rated 90/100Source typePeer-reviewed studyIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 underlying claimsStudies suggest NAD+ promotes protective cell responses and helps reduce oxidative cell damage.
Metabolic regulation
85/100Rated 85/100Source typePeer-reviewed studyIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 underlying claimsEvidence points to NAD+ enhancing oxidative metabolism and potentially improving markers related to diet-induced metabolic issues.
Cognitive function support
90/100Rated 90/100Source typePeer-reviewed studyIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 underlying claimsPreliminary research suggests NAD+ may support cognitive health and help counteract neurodegenerative conditions.
Aging & longevity pathways
95/100Rated 95/100Source typePeer-reviewed studyIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 5 underlying claimsResearch explores NAD+ restoration as a potential intervention to slow or reverse age-associated functional decline.
Liver protection
72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 1 underlying claimAnimal studies indicate NAD+ precursors may offer protective effects against specific forms of liver injury.
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Safety
Known Side Effects
Adverse effects reported in the research and by community use.
- Cellular Energy DepletionSevere 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ ncbi.nlm.nih.gov
Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.
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Evidence
Research Citations (30)
Every claim above traces back to a source you can check — here are 30 of them.
- Source
NAD+ metabolism in health and disease.
2007 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
The simultaneous measurement of nicotinamide adenine dinucleotide and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry.
2006 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.
2007 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
2007 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Regulation of Glucose Metabolism by NAD(+) and ADP-Ribosylation
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Regulation of Glucose Metabolism by NAD(+) and ADP-Ribosylation.
2019 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae.
2006 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders.
2016 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Regulatory Effects of NAD(+) Metabolic Pathways on Sirtuin Activity.
2018 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver.
1967 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
News
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