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5-Amino-1MQ

Also called: 5-amino-1-methylquinolinium, NNMT inhibitor, 1MQ

By The Health Stacks Research TeamUpdated July 28, 2026

5-Amino-1MQ is a small chemical compound used in research to study how the body burns fat and makes energy. It is not a protein, but it is often grouped with research peptides. It works by blocking a specific enzyme in the body called NNMT. Scientists study it to see how stopping this enzyme changes metabolism.

It is usually sold as a research chemical and is not approved by health groups for everyday use.Researchers are interested in this compound because it might help lower body fat and build muscle. By blocking the NNMT enzyme, it is thought to speed up how fast cells use energy. This process could help researchers understand new ways to treat obesity and metabolic problems. Some early tests show it helps cells burn more calories, but most of this information comes from laboratory experiments.There is no proof yet that this compound is safe or works well in humans.

Most of the testing has been done in labs or on animals, not on people. Because it is sold strictly for research, it is not meant to be eaten or used as a medicine by anyone. Buyers should know that it lacks official approval from groups like the FDA. Anyone handling it must be very careful and treat it as an unapproved lab chemical.

Research-stageEarly-stage — studied in cell or animal models, not yet tested in humans. Medium confidence40–59 — backed by moderate-quality sources. Worth a closer look at the individual citations.
Where to Source 5-Amino-1MQ
Tested purity COA available Fast shipping

What 5-Amino-1MQ Helps With

The benefits people report — backed by research.

Weight management (5)

Reduces appetite and increases satiety through triple monoamine reuptake inhibition 80/100· 4 srcSupports weight loss 85/100Reverses high-fat-diet-induced obesity 75/100Reduces adipocyte size and increases thermogenic markers 70/100Fat metabolism 60/100

Energy & mitochondrial (4)

NNMT inhibition increases NAD+ and improves metabolic profile 85/100Boosts energy 85/100Increased NAD+ levels 85/100Increase in intracellular NAD+ levels 60/100

Glycemic & metabolic (3)

Helps regulate blood sugar 85/100Improved glucose uptake 80/1005-Amino-1MQ acts as an NNMT inhibitor 70/100

Other Benefits (5)

Drives mitochondrial biogenesis, fat oxidation, and endurance gains 70/100· 4 srcHeals gut issues 80/100· 3 srcSupports weight loss 85/100Speeds muscle recovery 75/100Tissue repair and injury healing 60/100
5-Amino-1MQ — weight loss

How People Use It

Under the skin

  • 0.3–4.5 mg weekly

For research purposes only. Not medical advice. Talk to a doctor before use.

Get 5-Amino-1MQ for Your Research

Compare research-grade suppliers with third-party COAs and published purity data. For in-vitro and laboratory research use only — not for human consumption, diagnosis, or treatment.

Find 5-Amino-1MQ Research Suppliers
Tested purity COA available Fast shipping
Technical Details & Research (click to expand)

All Dosing Protocols

TesofensineSubQ 75/100

Research Citations (6)

  • Neelakantan et al., Sci Rep / preclinical (referenced via PMC) 5-amino-1MQ NNMT inhibition, mouse DIO model

    Source
  • Pissios, Trends Endocrinol Metab (2017) NNMT in metabolic disease

    Source
  • Kraus et al., Nature (2014) Nicotinamide N-methyltransferase as a metabolic switch

    Source
  • Inhibition of NNMT increases NAD+ levels

    Source
  • NNMT inhibition plus lean-diet (Sampson et al., 2021)

    Source
  • NNMT knockdown reduces fat mass (Kraus et al., 2014)

    Source

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