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Also called: 5-amino-1-methylquinolinium, NNMT inhibitor, 1MQ

By The Health Stacks Research TeamUpdated September 15, 2026

5-Amino-1MQ is a tiny lab-made chemical, not really a peptide at all, even though it is often sold alongside research peptides. It is studied for how it affects the way the body stores fat and uses energy. Scientists, metabolic clinics, and longevity researchers are the ones who pay the most attention to it. Some wellness clinics talk about it for fat loss and cellular energy.

Its main job in the lab is blocking an enzyme called NNMT. That enzyme helps control NAD+, a molecule cells need to make energy, and it is found at high levels in fat tissue. In animal and cell studies, blocking NNMT seems to help cells burn more energy and may reduce fat storage. This is why researchers find it interesting for studying metabolism, fat handling, and aging.

Most of what we know comes from lab and animal studies, not large human trials. So it is still unknown whether it works the same way in people, what a safe dose would be, or what side effects might appear. It is not approved by the FDA for any medical use, and products sold online are labeled for research only. Anyone curious about it should talk to a licensed doctor before considering it.

Research-stageEarly-stage — evidence so far is mostly cell, animal, or preliminary human studies. Not an approved medicine. Verified confidence80–100 — backed by strong, well-corroborated sources (peer-reviewed research, clinical guidelines). Our highest confidence tier.

Benefits

What 5-Amino-1MQ Helps With

The main themes across 2 research studies, in plain language.

Tissue repair & injury recovery

50/100Rated 50/100Source typeUnclassified sourceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 10 underlying claims

Preliminary research points to a role for NNMT inhibition in supporting tissue regeneration, muscle repair, and recovery from athletic injuries.

Research examplesBest source ↗

Gut health & systemic inflammation

40/100Rated 40/100Source typeVendor / seller pageIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 underlying claims

Studies suggest that tissue repair mechanisms may extend to the gut lining and help modulate systemic inflammation.

Research examplesBest source ↗

Weight management & metabolic health

80/100Rated 80/100Source typePeer-reviewed studyIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 13 underlying claims

Research suggests that inhibiting the NNMT enzyme may help reduce body fat, shrink fat cells, and improve markers of metabolic syndrome.

Research examplesBest source ↗

Fat metabolism & appetite control

40/100Rated 40/100Source typeVendor / seller pageIndependent sources5Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 9 underlying claims

Evidence suggests that this mechanism may mimic lipolytic signals to burn fat and support satiety, potentially aiding in appetite regulation.

Research examplesBest source ↗

Cognitive function & stress resilience

40/100Rated 40/100Source typeVendor / seller pageIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 underlying claims

Research suggests potential nootropic benefits, including support for focus, BDNF levels, and reduction in anxiety-related responses.

Research examplesBest source ↗

Skin repair & collagen support

40/100Rated 40/100Source typeVendor / seller pageIndependent sources5Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 underlying claims

Formulation research indicates potential benefits for skin repair and the maintenance of collagen structures.

Research examplesBest source ↗

Cellular energy & NAD+ optimization

50/100Rated 50/100Source typeUnclassified sourceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 11 underlying claims

Studies indicate that blocking NNMT can increase NAD+ levels, potentially boosting cellular energy expenditure and mitochondrial function.

Research examplesBest source ↗

Growth hormone axis support

40/100Rated 40/100Source typeVendor / seller pageIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 underlying claims

Research suggests the mechanism may work synergistically to support the release of growth hormone.

Research examplesBest source ↗

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How People Use It

1 reported routine — each line links to the source it came from.

From published sources

Routines as reported in peer-reviewed papers, clinical guidance, or vetted media — each linked to the source it came from.

SubQ

  • IV and oral administration (specific dose not specified in text) 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.

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