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AOD-9604

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Also called: AOD-9604 + BPC-157, AOD-9604 + GH Secretagogues (CJC-1295 / Ipamorelin), AOD-9604 + GH Secretagogues (CJC-1295/Ipamorelin)

By The Health Stacks Research TeamUpdated September 14, 2026

AOD-9604 is a small piece of a protein that scientists make in a lab. It is a copy of a tiny part of a larger hormone that helps children grow. Researchers look at this chemical to see how it acts on fat cells in the body. It is mostly used by scientists in labs, not by regular people for daily health.

The main reason researchers study this chemical is to see if it helps burn body fat. In simple terms, it might tell fat cells to break down their stored fat into energy. It does not seem to make the body grow bigger or build muscle like the full hormone does. Instead, it focuses only on the fat cells to see if they shrink or change how they work.

Right now, we do not know if it is safe or helpful for humans to use. The tests have mostly been done on animals or in small studies, so the results are not clear yet. It is not a legal medicine for people to take to lose weight. Because it is sold only for research, it should not be eaten or used as a drug. Scientists are still trying to understand if it works and what the side effects might be.

Research-stageEarly-stage — evidence so far is mostly cell, animal, or preliminary human studies. Not an approved medicine. Verified confidence80–100 — backed by strong, well-corroborated sources (peer-reviewed research, clinical guidelines). Our highest confidence tier.

Benefits

What AOD-9604 Helps With

The benefits people report — backed by research.

Weight management (11)

Anti-obesity potential 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcWeight management 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduction of body fat 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Lipolytic activity 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Stimulates lipolysis 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Inhibits lipogenesis 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Potential therapeutic candidate for the treatment of obesity 80/100Rated 80/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Stimulation of lipolysis in adipose tissue 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Fat loss without IGF-1 elevation 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →AOD-9604 stimulates lipolysis via beta-3 adrenergic receptors 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →AOD-9604 inhibits lipogenesis 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Glycemic & metabolic (5)

Modulation of lipid metabolism 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcIncreasing lipolytic sensitivity 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Insulin sensitivity 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →No elevation of IGF-1 levels or interference with glucose metabolism 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →AOD-9604 demonstrated fat reduction without affecting IGF-1 or glucose levels 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Antioxidant / oxidative stress (2)

Energy metabolism 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Increases in vivo fat oxidation 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Tissue & wound healing (2)

Lipolysis 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcCollagen production 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Musculoskeletal (2)

Potential support for cartilage repair 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Cartilage integrity improvement 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

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How People Use It

1 reported routine — each line links to the source it came from.

From published sources

Routines as reported in peer-reviewed papers, clinical guidance, or vetted media — each linked to the source it came from.

SubQ

  • Chronic ip administration for 14 days (specific dose not mentioned in text) 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.

Honest expectations

What AOD-9604 doesn’t do

What the sourced research says it doesn’t do — as notable as what it does.

Safety

Known Side Effects

Adverse effects reported in the research and by community use.

  • Hyperglycemia (induced by hGHModerate 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ doi.org
  • Reduced insulin secretion (induced by hGHModerate 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ doi.org
  • not AOD9604)Moderate 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ doi.org
  • not AOD9604)Moderate 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ doi.org
  • Mild injection-site reactionsMildReported in 2 sources 60/100Rated 60/100Source typeSpecialist communityIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org↗ peptide-db.com
  • Occasional mild headachesMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
  • Transient fatigue during the initial days of useMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
  • Injection-site reactionsMildReported in 2 sources 60/100Rated 60/100Source typeSpecialist communityIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org↗ peptidepedia.org
  • FatigueMildReported in 2 sources 60/100Rated 60/100Source typeSpecialist communityIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org↗ peptidedosingprotocols.com
  • NauseaModerateReported in 15 sources 60/100Rated 60/100Source typeSpecialist communityIndependent sources15Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org↗ canada.pharmalabglobal.com↗ america.pharmalabglobal.com↗ netherlands.pharmalabglobal.com+11
  • DiarrheaMildReported in 3 sources 60/100Rated 60/100Source typeSpecialist communityIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org↗ utherpeptide.com↗ peptidedosingprotocols.com
  • VomitingModerateReported in 2 sources 60/100Rated 60/100Source typeSpecialist communityIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org↗ utherpeptide.com
  • ConstipationMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org

Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.

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Shop AOD-9604
Code ths10 applied at checkout
Also available at PSPeptides — code ths10 works there too
Technical Details (sequence & mechanism — click to expand)

Amino Acid Sequence

AOD-960416 residues
Y
L
R
I
V
Q
C
R
S
V
E
G
S
C
G
F
Hydrophobic Acidic Basic Polar Aromatic

Mechanism of Action

AOD-9604 is a synthetic peptide corresponding to the C-terminal lipolytic fragment of human growth hormone (aa 177-191). It stimulates lipolysis and inhibits lipogenesis in adipose tissue - promoting fat oxidation and weight loss in animals - without affecting IGF-1 or glucose metabolism. It reached phase-II human trials but was not approved as an anti-obesity drug due to modest efficacy.

Evidence

Research Citations (4)

Every claim above traces back to a source you can check — here are 4 of them.

  • The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice.

    AnimalStudy2001 Key study 82/100Rated 82/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • AOD-9604 Metabolic.

    2004 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • AOD-9604 does not influence the WADA hGH isoform immunoassay.

    2013 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • PubChem - Compound - AOD9604 acetate

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

Timeline

History & Milestones

Key moments in AOD-9604’s research and regulatory timeline — sourced and dated.

  1. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolismPublicationDec 1, 2001
    Related:AOD-9604
    82/100Rated 82/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source
  2. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice.PublicationDec 1, 2001
    Related:AOD-9604
    90/100Rated 90/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source
  3. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormonePublicationJan 1, 2000
    Related:AOD-9604
    90/100Rated 90/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

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