Follistatin
Shop FollistatinAlso called: ACE-031 / Follistatin Combination, Follistatin-344 / GH Secretagogues Stack
Follistatin is a special protein that your body makes naturally. It works like a brake pedal for other signals in your body. Scientists put it in a group called glycoproteins. It is mostly used by researchers who study muscles and how bodies grow. Some people who are very interested in fitness and bodybuilding also look at this protein.
The main job of Follistatin is to stop a substance called activin. It also stops something called myostatin. Myostatin tells muscles to stop growing. By blocking myostatin, Follistatin might help muscles grow bigger and stronger. This is why many studies look at it for diseases that make muscles weak.
It helps the body build more tissue by stopping the 'stop' signals. We do not know yet if it is safe for humans to use as a medicine. Most of the tests have been done on animals or in small labs. There is no big proof that it works well in people yet. Because it is so strong, it could have bad side effects. It is mostly sold only for research purposes right now.
Benefits
What Follistatin Helps With
The benefits people report — backed by research.
Benefits (3)
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Safety
Known Side Effects
Adverse effects reported in the research and by community use.
- Potential Hormonal ImbalanceModerate 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ pubmed.ncbi.nlm.nih.gov
Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.
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Evidence
Research Citations (50)
Every claim above traces back to a source you can check — here are 50 of them.
- Source
FST follistatin [Homo sapiens (human)] - Gene
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
FST follistatin [ Homo sapiens (human) ]
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Fst follistatin [ Mus musculus (house mouse) ]
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone.
1987 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Human follistatin-related protein: a structural homologue of follistatin with nuclear localization
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Human follistatin-related protein: a structural homologue of follistatin with nuclear localization.
2001 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy.
2009 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Elevated circulating follistatin associates with an increased risk of type 2 diabetes
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Elevated circulating follistatin associates with an increased risk of type 2 diabetes.
2021 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Elevated circulating follistatin associates with increased risk of mortality and cardiometabolic disorders
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Elevated circulating follistatin associates with increased risk of mortality and cardiometabolic disorders.
2024 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
The activin-follistatin system: Key regulator of kidney development, regeneration, inflammation, and fibrosis
72/100Rated 72/100Source typeEstablished referenceIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Identification of follistatin as a possible trait-causing gene in polycystic ovary syndrome
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
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