Parathyroid hormone

Shop Parathyroid hormone
Code ths10 applied at checkout

Also called: Parathyroid hormone (1-34) (human), Parathyroid Hormone (1-34), bovine, TIP 39, Tuberoinfundibular Neuropeptide, Parathyroid Hormone 2 Receptor Agonist

By The Health Stacks Research TeamUpdated September 20, 2026

Parathyroid hormone is a natural substance your body makes in four tiny glands in your neck. These glands sit behind the thyroid gland. The hormone's main job is to control the amount of calcium in your blood. Calcium is a mineral your body needs for strong bones, working muscles, and healthy nerves.

When the calcium in your blood gets too low, the glands release this hormone. It tells your bones to release some stored calcium, tells your kidneys to hold onto calcium instead of flushing it out, and helps your body absorb calcium from food. Scientists have also made medicines from this hormone. These medicines are given as shots and can help build new bone in people whose bones are weak and break easily.

Most of what we know comes from studies of the injectable medicine, and its safety over very long use is still being studied. Researchers are also working on pill forms, because shots can be hard for people to take every day, but oral versions are still being tested. Anyone thinking about using it should talk to a doctor first, since changing calcium levels can be dangerous.

ApprovedApproved by a regulator (e.g. FDA) for a specific medical use — the highest research-status tier. High confidence60–79 — backed by solid sources with good corroboration across multiple citations.

Benefits

What Parathyroid hormone Helps With

The benefits people report — backed by research.

Reproductive & hormonal (11)

Cinacalcet mimics circulating calcium to reduce parathyroid hormone release 72/100Rated 72/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcParathyroid hormone restores blood calcium levels 72/100Rated 72/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcHigh baseline levels associated with single-gland disease 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Intraoperative PTH assay confirms correct adenoma removal when PTH drops >50% from preoperative level 10 minutes post-gland removal 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Parathyroid hormone replacement treats hypocalcaemia caused by hypoparathyroidism 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →PTH replacement therapy relieves symptoms and minimizes complications of hypoparathyroidism 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Regulates placental calcium transfer and fetal calcium regulation 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →PTH replacement therapy may change treatment approaches for hypoparathyroidism 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Parathyroid hormone replacement for hypoparathyroidism management 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Calcium and active vitamin D maintain satisfactory blood calcium levels 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Parathyroid hormone maintains blood calcium homeostasis 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Musculoskeletal (8)

Bone repair 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcTreat osteoporosis 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Regulates blood calcium levels 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Stimulates osteoblast proliferation via activation of protein kinase C and Src-dependent VEGFR2 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Maintenance of extracellular calcium concentrations 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Stimulates osteoblast proliferation via protein kinase C and VEGFR2 activation 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Vitamin D supplementation restores calcium levels in deficiency states 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Muscle recovery 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Renal & hepatic (7)

Parathyroid hormone increases renal calcium resorption and phosphate excretion 72/100Rated 72/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcLiver health 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →PTH stimulates kidneys to resorb calcium and excrete phosphorus 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Stimulates kidneys to increase vitamin D metabolism 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduces urinary calcium loss via action on kidneys 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduces urinary calcium loss by acting on the kidneys 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Prevention of kidney disease in chronic Hypoparathyroidism 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Glycemic & metabolic (5)

Primary regulator of blood calcium levels 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Active vitamin D combined with calcium maintains satisfactory blood calcium levels 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Insulin sensitivity 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Parathyroid hormone converts 25-hydroxyvitamin D to active 1,25-dihydroxyvitamin D-3 via 1-hydroxylase activation 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Cinacalcet reduces blood calcium levels in primary hyperparathyroidism 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Gastrointestinal & gut (3)

PTH indirectly stimulates intestinal calcium and phosphorus absorption by converting 25-hydroxy vitamin D to 1,25-dihydroxy vitamin D in proximal renal tubules 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Gastric / gut lining 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Stimulates active vitamin D production in kidneys to increase intestinal calcium absorption 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Cardiovascular & vascular (2)

Hirudin acts as a prophylaxis for Deep Vein Thrombosis 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Angiogenesis 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

More reported benefits (4)

Vitamin D supplementation treats secondary hyperparathyroidism 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Intraoperative decline >70% linked to better recurrence-free survival 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduction of immunogenicity 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Improvement in quality of life 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Free: The Peptide Stack Cheat-Sheet

You just read the research on Parathyroid hormone. The cheat-sheet maps the most-used peptide stacks — doses, timing, and what to check before buying — on one page.

No spam. Unsubscribe anytime.

Safety

Known Side Effects

Adverse effects reported in the research and by community use.

  • TachyphylaxisModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Electrolyte abnormalities (hyperphosphatemiaModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Nausea and vomitingMildReported in 2 sources 72/100Rated 72/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com↗ emedicine.medscape.com
  • HeadacheMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Muscle weakness and fatigueMildReported in 2 sources 72/100Rated 72/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com↗ emedicine.medscape.com
  • Increased thirstMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Increased urine productionMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Abdominal painModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • ConstipationMildReported in 3 sources 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info↗ yourhormones.info↗ yourhormones.info
  • Generalised aches and painsMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Tingling or pins and needle sensationsModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Muscle cramps or spasmsModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Hypercalcemia of malignancySevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Osteoporosis (from excess PTH / primary hyperparathyroidism)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Kidney stones (from excess PTH / primary hyperparathyroidism)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Hypocalcaemia (from insufficient PTH / hypoparathyroidism)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Chalky taste in the mouthMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Stomach painMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • DiarrhoeaMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Kidney stonesModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Nephrocalcinosis (calcium deposits in the kidneys)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Constipation from calcium tabletsMildReported in 2 sources 72/100Rated 72/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info↗ yourhormones.info
  • Increased thirst and urine production (hypercalcaemia)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Abdominal pain and constipation (hypercalcaemia)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • TinglingModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Coma and death (in severe hypercalcemia)LifeThreatening 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Depression and confusion (Neuropsychiatric manifestations)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Peptic ulcer diseaseModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • PancreatitisSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Osteopenia / bone lossModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Renal stones (nephrolithiasis)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • PTHrP-mediated osteolysis promoting tumor cell colonies in boneSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Calcitonin tachyphylaxisModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Bisphosphonate-induced electrolyte abnormalities (hyperphosphatemiaModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Hypercalcemia-associated nausea and vomitingModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Calciphylaxis (dermatologic complication with skin ulceration and necrosis)LifeThreatening 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Hoarse voice from vocal cord nerve damageModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Temporary low calcium levels after surgeryModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Permanently low calcium levels requiring life-long supplementationSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Thirst and frequent urination from high calciumMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Abdominal painModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Tiredness, aches, poor concentration, low mood, and confusionMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Chalky taste in mouth from calcium supplementationMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Constipation from calcium supplementationMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Stomach pain from high-dose calcium supplementation (>1Mild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Diarrhoea from high-dose calcium supplementation (>1Mild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Raised blood calcium (hypercalcaemia) from vitamin D treatmentModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • hypophosphatemiaModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • hypocalcemiaModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • hypomagnesemia)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • pins and needlesModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • muscle cramps/spasms (hypocalcaemia)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • hypophosphatemiaModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • hypocalcemiaModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • hypomagnesemia)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • ConstipationModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • and nausea from high calciumModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • 500mg/day)Mild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • 500mg/day)Mild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • HypophosphatemiaModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • HypocalcemiaSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • HyperphosphatemiaModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com

Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.

Get Parathyroid hormone

Compare research-grade suppliers with third-party COAs and published purity data. For in-vitro and laboratory research use only — not for human consumption, diagnosis, or treatment.

Shop Parathyroid hormone
Code ths10 applied at checkout

Evidence

Research Citations (1)

Every claim above traces back to a source you can check — here are 1 of them.

  • Screening for parathyroid hormone resistance in patients with nonphenotypically evident pseudohypoparathyroidism

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

Timeline

History & Milestones

Key moments in Parathyroid hormone’s research and regulatory timeline — sourced and dated.

  1. Activation of Renal Cortical Adenylate Cyclase by Circulating Immunoreactive Parathyroid Hormone FragmentsPublicationFeb 1, 1973
    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

News

Latest on Parathyroid hormone

Dated, sourced reporting that mentions Parathyroid hormone.

Regulatory

FDA approves new drug for hypoparathyroidism, a rare disorder

FDA approved Yorvipath (palopegteriparatide) injection for subcutaneous use in adults with hypoparathyroidism — the first FDA-approved hormone replacement for adults with the rare disorder. The approval drew on an 82-patient, 26-week trial in which 69% of Yorvipath patients versus 5% of placebo patients maintained normal calcium without active vitamin D or high-dose calcium supplements. The application received orphan drug designation and priority review; the drug was not studied in acute post-surgical hypoparathyroidism.

90/100Rated 90/100Source typeRegulator or clinical registryIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →
Safety

FINAL NOTICE: NATPARA SPECIAL USE PROGRAM CLOSES DECEMBER 31, 2025 (letter to healthcare providers, hosted by FDA)

In this final notice, Takeda states that, in alignment with the US FDA, the NATPARA Special Use Program (SUP) closes on December 31, 2025, and no NATPARA shipments will be sent after that date. The letter follows the previously communicated global manufacturing discontinuation of NATPARA in December 2024. Prescribers are urged to develop alternate treatment plans for enrolled patients, including potential transition to the FDA-approved treatment for adult hypoparathyroidism (the letter links Yorvipath's prescribing information).

90/100Rated 90/100Source typeRegulator or clinical registryIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →
Market

After years of manufacturing woes, Takeda is calling it quits on Natpara

Fierce Pharma reports that Takeda is ending all manufacturing of Natpara for hypoparathyroidism in the US and abroad by the end of 2024 and will not return the drug to the US market, after a 2019 recall for rubber particulate fears and a Complete Response Letter from FDA. The story notes roughly 2,800 patients relied on Natpara before the recall and that the drug earned $230 million in 2018, its last full reported US sales year. Takeda said it cannot implement a solution to the rubber particle formation issue.

72/100Rated 72/100Source typeEstablished referenceIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →

Wondering how Parathyroid hormone pricing compares across suppliers? Our original market data shows the full picture.

See the State of the Peptide Market 2026 →

Free: The Peptide Stack Cheat-Sheet

The most-used peptide combinations, what the research actually says, and where to buy — one page, one email.

No spam. Unsubscribe anytime.