Also called: Melanotan-2, MT II, MT2

By The Health Stacks Research TeamUpdated September 15, 2026

Melanotan II is a man-made copy of a natural body chemical that controls skin color. It is not a real medicine. It is usually sold as a powder that people mix and inject under the skin. People who want a tan without much sun often look for it online.

Its main effect is that it tells skin cells to make more of the dark pigment that gives skin a tan color. It may also lower appetite and cause erections in men. The tanning effect is the reason most people try it. It became popular because a tan can appear with little time in the sun.

There is no strong proof it is safe. No big health group has approved it, and doctors do not know if the products sold online are clean or even real. It can cause nausea, flushing, and unwanted dark spots on the skin. Health agencies warn people not to buy or inject it because it is made in unknown places with unknown quality.

Research-stageEarly-stage — evidence so far is mostly cell, animal, or preliminary human studies. Not an approved medicine. High confidence60–79 — backed by solid sources with good corroboration across multiple citations.

Benefits

What Melanotan II Helps With

The main themes across 16 research studies, in plain language.

Neuroprotection & cognitive

Neuroprotection & cognitive repair

40/100Rated 40/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 9 underlying claims

Animal model research points to potential mechanisms for reducing brain inflammation, protecting against ischemic damage, and promoting nerve regeneration.

Research examplesBest source ↗

Autism symptom modulation

30/100Rated 30/100Source typeForum or blogIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 1 underlying claim

Limited research suggests potential for modulating neural circuits associated with social behaviors and autism symptoms.

Research examplesBest source ↗

Skin, hair & cosmetic

Skin pigmentation & tanning

50/100Rated 50/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 34 underlying claims

Research suggests that stimulation of melanin production may lead to darker skin pigmentation and tanning effects, potentially with reduced UV exposure.

Research examplesBest source ↗

Hair pigmentation changes

35/100Rated 35/100Source typeUnclassified sourceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 underlying claims

Evidence indicates that increased melanin activity may result in the darkening of facial and body hair.

Research examplesBest source ↗

Appetite & weight control

40/100Rated 40/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 underlying claims

Preliminary findings suggest a role in regulating hypothalamic pathways to potentially suppress appetite and decrease food intake.

Research examplesBest source ↗

Blood flow & circulation

30/100Rated 30/100Source typeUnclassified sourceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 1 underlying claim

Research notes potential effects on vascular function that may improve circulation.

Research examplesBest source ↗

Sexual function & libido

50/100Rated 50/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 12 underlying claims

Studies indicate that modulation of specific pathways may influence sexual desire, arousal, and erectile responses.

Research examplesBest source ↗

Thermogenic response

40/100Rated 40/100Source typeUnclassified sourceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 1 underlying claim

Some studies point to an ability to trigger metabolic heat production processes.

Research examplesBest source ↗

Alternative delivery methods

40/100Rated 40/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 underlying claims

Consumer interest exists in needle-free formulations, though comparative efficacy data is limited.

Research examplesBest source ↗

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How People Use It

1 reported routine — each line links to the source it came from.

Self-reported & vendor-suggested

Routines shared by users and sellers in forums and product pages — anecdotal, not tested in clinical trials. We show them for completeness, not as a recommendation.

General

  • 250–1000 mcg once daily SC (loading), then 500–1000 mcg 1–2×/week 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source
    1. Week 1 — 250 mcg (0.25 mg) · 7.5 units (0.075 mL)
    2. Week 2 — 500 mcg (0.5 mg) · 15 units (0.15 mL)
    3. Week 3 — 750 mcg (0.75 mg) · 22.5 units (0.225 mL)
    4. Weeks 4–8 — 1000 mcg (1 mg) · 30 units (0.30 mL)
    5. Maintenance(after Week 8) — 500–1000 mcg(1–2× weekly) · 15–30 units(0.15–0.30 mL)

mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.

Safety

Known Side Effects

Adverse effects reported in the research and by community use.

  • Somnolence and fatigue (Grade II)Moderate 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ pubmed.ncbi.nlm.nih.gov
  • Mild nauseaMildReported in 4 sources 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ pubmed.ncbi.nlm.nih.gov↗ peptide-db.com↗ thepeptidecatalog.com↗ thepeptidecatalog.com
  • Stretching and yawning complexMild 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ pubmed.ncbi.nlm.nih.gov
  • Spontaneous erections (priapism) 1-5 hours after administrationSevereReported in 4 sources 72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ dermnetnz.org↗ dermnetnz.org↗ dermnetnz.org↗ dermnetnz.org
  • Melanoma (potentially serious skin cancer)Severe 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ dermnetnz.org
  • Deepening of mole colourModerateReported in 2 sources 72/100Rated 72/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ dermnetnz.org↗ dermnetnz.org
  • Melanonychia (brown to black discolouration of nails)ModerateReported in 4 sources 72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ dermnetnz.org↗ dermnetnz.org↗ dermnetnz.org↗ dermnetnz.org
  • Rhabdomyolysis (destruction of muscle cells)LifeThreatening 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ dermnetnz.org
  • Encephalopathy syndromeSevereReported in 4 sources 72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ dermnetnz.org↗ dermnetnz.org↗ dermnetnz.org↗ dermnetnz.org
  • Stomach crampsMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ rxlist.com
  • TirednessMildReported in 2 sources 72/100Rated 72/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ rxlist.com↗ thinksteroids.com
  • Spontaneous erections of the penisModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ rxlist.com
  • new moles and atypical melanocytic naeviModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ dermnetnz.org
  • Uneven skin darkeningModerate 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
  • New moles or enlargement of existing molesModerate 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
  • Melanonychia (dark lines on nails)Moderate 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
  • NauseaMildReported in 19 sources 70/100Rated 70/100Source typeEstablished referenceIndependent sources19Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com↗ puremt2.com↗ puremt2.com↗ trutan.net+15
  • Facial redness or flushingMild 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
  • Reduced appetiteMild 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
  • Priapism (painful prolonged erection)Severe 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
  • Melanoma (Skin Cancer)LifeThreatening 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
  • Severe Allergic ReactionSevere 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
  • VomitingMildReported in 11 sources 70/100Rated 70/100Source typeEstablished referenceIndependent sources11Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com↗ canada.pharmalabglobal.com↗ america.pharmalabglobal.com↗ italy.pharmalabglobal.com+7
  • HeadacheMild 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
  • Deepening of the colour of molesModerateReported in 2 sources 70/100Rated 70/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ dermnetnz.org↗ dermnetnz.org
  • new moles and atypical melanocytic naeviModerate 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ dermnetnz.org
  • Facial flushing and warmthMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
  • Fatigue or drowsinessMild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
  • Spontaneous or prolonged erections in menModerate 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
  • Development of new nevi (moles)Moderate 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org
  • Injection site reactions (redness, pain, swelling)Mild 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ peptidepedia.org

Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.

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Technical Details (sequence & mechanism — click to expand)

Mechanism of Action

Melanotan II is a synthetic cyclic heptapeptide and non-selective melanocortin receptor agonist (MC1R/MC3R/MC4R/MC5R). MC1R agonism darkens skin (tanning); MC4R effects increase libido and induce erections. It is NOT approved by the FDA/TGA/EMA and is sold illicitly; regulators warn against use due to significant safety risks.

Evidence

Research Citations (9)

Every claim above traces back to a source you can check — here are 9 of them.

  • TGA warning: tanning products containing melanotan

    Guideline2023 Key study 70/100Rated 70/100Source typeRegulator or clinical registryIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • Melanotan-induced priapism: a hard-earned tan

    CaseReport2019 60/100Rated 60/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • melanotan-II

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • PubChem - Compound - Melanotan II

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • The first preparative solution phase synthesis of melanotan II.

    2008 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • Effect of Melanotan-II on Brain Fos Immunoreactivity and Oxytocin Neuronal Activity and Secretion in Rats.

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • Combining MALDI mass spectrometry imaging and droplet-base surface sampling analysis for tissue distribution, metabolite profiling, and relative quantification of cyclic peptide melanotan II

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • melanotan-II | C50H69N15O9 | CID 92432 - PubChem

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source
  • Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

News

Latest on Melanotan II

Dated, sourced reporting that mentions Melanotan II.

ClinicalOct 2, 2000

Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II | International Journal of Impotence Research

A clinical trial involving 20 men with erectile dysfunction found that the synthetic peptide Melanotan II, a melanocortin receptor agonist, significantly induced penile erections and increased sexual desire compared to a placebo. While the peptide demonstrated efficacy in initiating erections even without sexual stimulation, treatment was associated with a high frequency of side effects, specifically nausea and yawning.

72/100Rated 72/100Source typeEstablished referenceIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →
Regulatory

Tailor Made Compounding LLC

FDA warned Tailor Made Compounding LLC (Nicholasville, KY) after a 2018 inspection found it compounded drug products with bulk substances ineligible for 503A exemptions. The letter explicitly lists the compounded substances: Follistatin, GHRP-2, GHRP-6, AOD 9604, BPC 157, Bremelanotide (PT-141), Cerebrolysin, DSIP, Epitalon, GHK-Cu, Ipamorelin, LL-37, Melanotan II, Selank, Semax, and CJC 1295, among others. The firm was cited for insanitary aseptic processing (adulteration), unapproved new drugs, and misbranding, and removed GHRP-2 and GHRP-6 from its formulary in response.

90/100Rated 90/100Source typeRegulator or clinical registryIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →

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