Melanotan II
Shop Melanotan IIAlso called: Melanotan-2, MT II, MT2
Melanotan II is a synthetic cyclic heptapeptide and non-selective melanocortin receptor agonist (MC1R/MC3R/MC4R/MC5R). MC1R agonism darkens skin (tanning); MC4R effects increase libido and induce erections. It is NOT approved by the FDA/TGA/EMA and is sold illicitly; regulators warn against use due to significant safety risks.
Benefits
What Melanotan II Helps With
The main themes across 3 research studies, in plain language.
Neuroprotection & cognitive
Neuroprotection & cognitive repair
40/100Rated 40/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 9 underlying claimsAnimal model research points to potential mechanisms for reducing brain inflammation, protecting against ischemic damage, and promoting nerve regeneration.
Autism symptom modulation
30/100Rated 30/100Source typeForum or blogIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 1 underlying claimLimited research suggests potential for modulating neural circuits associated with social behaviors and autism symptoms.
Skin, hair & cosmetic
Skin pigmentation & tanning
50/100Rated 50/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 34 underlying claimsResearch suggests that stimulation of melanin production may lead to darker skin pigmentation and tanning effects, potentially with reduced UV exposure.
Hair pigmentation changes
35/100Rated 35/100Source typeUnclassified sourceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 underlying claimsEvidence indicates that increased melanin activity may result in the darkening of facial and body hair.
Appetite & weight control
40/100Rated 40/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 underlying claimsPreliminary findings suggest a role in regulating hypothalamic pathways to potentially suppress appetite and decrease food intake.
Blood flow & circulation
30/100Rated 30/100Source typeUnclassified sourceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 1 underlying claimResearch notes potential effects on vascular function that may improve circulation.
Sexual function & libido
50/100Rated 50/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 12 underlying claimsStudies indicate that modulation of specific pathways may influence sexual desire, arousal, and erectile responses.
Thermogenic response
40/100Rated 40/100Source typeUnclassified sourceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 1 underlying claimSome studies point to an ability to trigger metabolic heat production processes.
Alternative delivery methods
40/100Rated 40/100Source typeUnclassified sourceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 underlying claimsConsumer interest exists in needle-free formulations, though comparative efficacy data is limited.
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Safety
Known Side Effects
Adverse effects reported in the research and by community use.
- Uneven skin darkeningModerate 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
- New moles or enlargement of existing molesModerate 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
- Melanonychia (dark lines on nails)Moderate 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
- NauseaMildReported in 19 sources 70/100Rated 70/100Source typeEstablished referenceIndependent sources19Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com↗ puremt2.com↗ puremt2.com↗ trutan.net+15
- Facial redness or flushingMild 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
- Reduced appetiteMild 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
- Priapism (painful prolonged erection)Severe 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
- Melanoma (Skin Cancer)LifeThreatening 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
- Severe Allergic ReactionSevere 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
- VomitingMildReported in 11 sources 70/100Rated 70/100Source typeEstablished referenceIndependent sources11Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com↗ canada.pharmalabglobal.com↗ america.pharmalabglobal.com↗ italy.pharmalabglobal.com+7
- HeadacheMild 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ webmd.com
Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.
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Technical Details (sequence & mechanism — click to expand)
Mechanism of Action
Melanotan II is a synthetic cyclic heptapeptide and non-selective melanocortin receptor agonist (MC1R/MC3R/MC4R/MC5R). MC1R agonism darkens skin (tanning); MC4R effects increase libido and induce erections. It is NOT approved by the FDA/TGA/EMA and is sold illicitly; regulators warn against use due to significant safety risks.
Evidence
Research Citations (3)
Every claim above traces back to a source you can check — here are 3 of them.
- Source
TGA warning: tanning products containing melanotan
Guideline2023 Key study 70/100Rated 70/100Source typeRegulator or clinical registryIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Melanotan-induced priapism: a hard-earned tan
CaseReport2019 60/100Rated 60/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
News
Latest on Melanotan II
Dated, sourced reporting that mentions Melanotan II.
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