Desmopressin
Shop DesmopressinAlso called: Desmopressin Acetate, Desmoda (desmopressin acetate)
Desmopressin is a man-made copy of a natural body chemical called vasopressin. Vasopressin tells the kidneys to hold onto water instead of making urine. Doctors give desmopressin to people whose bodies don't make enough of this chemical on their own. When a person takes desmopressin, their kidneys keep more water in the body.
This means they make less urine and don't feel as thirsty. In one study, three people taking desmopressin were able to use smaller amounts after starting a different kind of diabetes medicine. The medicine changed how their bodies handled salt and water, so less desmopressin was needed to keep them feeling well. Scientists are still learning about how desmopressin works together with other medicines.
Taking too much can make the body hold too much water, which can be dangerous. Anyone using desmopressin needs a doctor to watch their dose carefully. More research with more people is needed to confirm how these medicines affect each other.
Benefits
What Desmopressin Helps With
The benefits people report — backed by research.
Glycemic & metabolic (5)
Renal & hepatic (2)
Reproductive & hormonal (1)
More reported benefits (4)
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How People Use It
1 reported routine — each line links to the source it came from.
From published sources
Routines as reported in peer-reviewed papers, clinical guidance, or vetted media — each linked to the source it came from.
SubQ
- Individualized; adjusted according to diurnal pattern of response 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source
mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.
Safety
Known Side Effects
Adverse effects reported in the research and by community use.
- Temporary loss of sensation of smellMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- Diabetes Insipidus (increased thirst and urination)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- Temporary weakness and mood changes from cortisol suppressionModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- Liver and kidney side-effects from cortisol-reducing tabletsSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- Loss of sensation of smellMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- Mood changes and weaknessMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.
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Timeline
History & Milestones
Key moments in Desmopressin’s research and regulatory timeline — sourced and dated.
- Desmopressin in moderate hemophilia A patients: a treatment worth consideringPublicationMar 1, 2018Related:Desmopressin
- A systematic review of the efficacy and safety of desmopressin for nocturia in adultsPublicationSep 1, 2014Related:Desmopressin
- Desmopressin in the treatment of nocturia: clinical evidence and experiencePublicationDec 1, 2013Related:Desmopressin
News
Latest on Desmopressin
Dated, sourced reporting that mentions Desmopressin.
Alternatives to Recalled Desmopressin Nasal Spray
The foundation recaps the 2020 Ferring recall of intranasal desmopressin (DDAVP/Stimate) for superpotency and notes that in June 2022 the company said the nasal spray would not be available until mid-2024 at the earliest. It lists practical alternatives for patients with von Willebrand disease and mild hemophilia A: STAQ Pharma's DDAVP nasal spray (distributing since September 2021), tranexamic acid or aminocaproic acid, IV or subcutaneous DDAVP, and factor replacement for severe cases.
Ferring US Issues Voluntary Nationwide Recall of DDAVP Nasal Spray 10 mcg/0.1mL, Desmopressin Acetate Nasal Spray 10 mcg/0.1mL, STIMATE Nasal Spray 1.5 mg/mL Due to Superpotency
Ferring Pharmaceuticals US voluntarily recalled all marketed lots of DDAVP Nasal Spray, Desmopressin Acetate Nasal Spray and STIMATE Nasal Spray nationwide to the consumer level after routine stability testing found the products were superpotent. FDA's notice states the risk of excess desmopressin is abnormally low blood sodium (hyponatremia), which could eventually lead to seizure, coma, and death. One non-fatal adverse event potentially associated with the issue had been reported in the US.
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