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Calcitonin

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Also called: Calcitonin, rat

By The Health Stacks Research TeamUpdated September 15, 2026

Calcitonin is a natural hormone made in the body, specifically by a gland in the neck called the thyroid. It is classified as a peptide hormone, which means it is a small protein that acts like a signal in the body. This hormone is very important because it helps control the level of calcium in the blood. Doctors and scientists often study it to understand how bones work and how to treat certain bone diseases. It is mostly used by medical professionals to help patients with bone problems.

The main job of calcitonin is to lower calcium levels in the blood when they get too high. It does this by telling the bones to stop releasing calcium and the kidneys to let more calcium leave the body in urine. This action helps protect the bones from losing too much strength. Because of this, it is used to treat a condition called Paget's disease and certain types of bone loss. It helps slow down the breakdown of bone, keeping them stronger for longer.

While calcitonin is helpful, there are still things researchers are trying to understand. It is not a first-choice treatment for all bone problems anymore because newer medicines often work better. It can sometimes cause side effects like nausea or flushing of the face. It is usually given as a shot or a nasal spray. Patients should always follow their doctor's advice when using this medicine to ensure it is safe and effective for their specific needs.

ApprovedApproved by a regulator (e.g. FDA) for a specific medical use — the highest research-status tier. Verified confidence80–100 — backed by strong, well-corroborated sources (peer-reviewed research, clinical guidelines). Our highest confidence tier.

Benefits

What Calcitonin Helps With

The benefits people report — backed by research.

Musculoskeletal (8)

Reduces blood calcium levels by inhibiting osteoclast activity 72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 srcBone repair 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 srcCalcitonin regulates calcium balance 72/100Rated 72/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcControl of symptoms and disease activity in Paget's disease 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Calcitonin has a role in calcium balance 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Calcitonin reduces blood calcium levels 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Bisphosphonates reduce blood calcium levels in hypercalcaemia 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Denosumab used in treatment of hypercalcaemia 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Reproductive & hormonal (7)

Calcitonin has a relatively minor role in calcium balance in humans 72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 srcCorticotrophin-releasing hormone drives the body's stress response 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 srcGrowth hormone therapy in childhood-onset deficiency helps achieve relatively normal height and development 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Growth hormone therapy helps children with GH deficiency achieve normal height 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Somatostatin inhibits secretion of various endocrine hormones 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Corticotrophin-releasing hormone is the main element driving the body's stress response 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Growth hormone deficiency treatment allows children to achieve relatively normal height and development 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Glycemic & metabolic (4)

Rapid lowering of blood calcium levels in severe hypercalcemia emergencies 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Calcitonin acts to reduce blood calcium levels 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Calcitonin used rarely as a medication to help manage severe hypercalcaemia 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Insulin sensitivity 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Cancer / tumor (3)

Calcitonin as a biomarker for Medullary Thyroid Carcinoma 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Calcitonin levels predict disease-free survival in hereditary MTC 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Diagnosis and monitoring of Medullary Thyroid Carcinoma 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Gastrointestinal & gut (2)

Cholecystokinin aids digestion and reduces appetite after a meal 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 srcCholecystokinin aids digestion and reduces appetite 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 src

Antimicrobial & antiviral (2)

Antimicrobial peptide design against KatG using molecular docking 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Peptide analogs induce multi-aggregate formation and impair cell division in Candida albicans 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

More reported benefits (5)

Decreases calcium reabsorption in the kidneys 72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 srcCorticotrophin-releasing hormone is the main element driving the body's response to stress 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 srcImmune modulation 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 srcGrowth hormone therapy in childhood-onset deficiency helps children achieve relatively normal height and development 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Novel melittin-based inhibitor of tyrosinase and MITF using machine-learning 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

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Safety

Known Side Effects

Adverse effects reported in the research and by community use.

  • C-cell Hyperplasia (Rodents)Moderate 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ pubmed.ncbi.nlm.nih.gov
  • TachyphylaxisModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Hypocalcemia following total thyroidectomy for MTCModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Impaired kidney function from bisphosphonatesModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Worsening of heart failure symptoms from excessive fluid replacementSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Low blood calcium levels following parathyroid surgeryModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Excessive fluid replacement worsening heart failure symptomsModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Bisphosphonates causing impaired kidney functionModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Low blood calcium following parathyroid surgeryModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info

Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.

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Evidence

Research Citations (57)

Every claim above traces back to a source you can check — here are 57 of them.

  • CALCA calcitonin related polypeptide alpha [ Homo sapiens (human) ]

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calca calcitonin/calcitonin-related polypeptide, alpha [ Mus musculus (house mouse) ]

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Evidence for Conservation of the Calcitonin Superfamily and Activity-regulating Mechanisms in the Basal Chordate Branchiostoma floridae: INSIGHTS INTO THE MOLECULAR AND FUNCTIONAL EVOLUTION IN CHORDATES

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Evidence for Conservation of the Calcitonin Superfamily and Activity-regulating Mechanisms in the Basal Chordate Branchiostoma floridae: INSIGHTS INTO THE MOLECULAR AND FUNCTIONAL EVOLUTION IN CHORDATES.

    2016 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin, the forgotten hormone: does it deserve to be forgotten?

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin, the forgotten hormone: does it deserve to be forgotten?

    2015 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Long-term effects of elevated gastrin levels on calcitonin secretion.

    2006 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin and human renal calcium and electrolyte transport.

    1997 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice.

    2008 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin plays a critical role in regulating skeletal mineral metabolism during lactation

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin plays a critical role in regulating skeletal mineral metabolism during lactation.

    2006 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.

    1986 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin-a hormone from the parathyroid which lowers the calcium-level of the blood.

    1962 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

Timeline

History & Milestones

Key moments in Calcitonin’s research and regulatory timeline — sourced and dated.

  1. Calcitonin and calcitonin receptorsPublicationMay 1, 2007
    Related:Calcitonin
    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source
  2. Calcitonin and calcitonin receptors: bone and beyondPublicationDec 1, 2000
    Related:Calcitonin
    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

News

Latest on Calcitonin

Dated, sourced reporting that mentions Calcitonin.

ResearchJul 19, 2024

The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer | Nature Communications

A Nature Communications study shows that medullary thyroid cancer (MTC) expresses CGRP, which shapes an immunosuppressive tumor microenvironment by altering dendritic cell development via cAMP/KLF2 pathways and impairing T cell activity. A CGRP receptor antagonist reversed these effects in vitro. The findings propose the CGRP receptor as a potential therapeutic target in MTC.

72/100Rated 72/100Source typeEstablished referenceIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →
Research

Article metrics for The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer | Nature Communications

A Nature Communications study reports that calcitonin gene-related peptide (CGRP), a neurotransmitter peptide, contributes to an immunosuppressive tumor microenvironment in medullary thyroid cancer. The findings suggest CGRP signaling may help the cancer evade immune attack and could represent a therapeutic target. The article metrics page itself is only a wrapper, but the underlying paper centers on CGRP biology in cancer immunology.

72/100Rated 72/100Source typeEstablished referenceIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →

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