Calcitonin

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Also called: Calcitonin, rat

By The Health Stacks Research TeamUpdated September 20, 2026

Calcitonin is a tiny protein-like message that your own body makes. It is made mostly in a small gland in your neck called the thyroid. Scientists have studied it for many decades, and it is also used as an ingredient in medicines. Doctors and researchers are interested in it because it is a real hormone that the body already knows how to use.

Calcitonin is part of a hormone system that helps control calcium, the mineral that keeps bones strong. Research also shows that one gene can make two different products: calcitonin in the thyroid, and a related message-carrying protein called CGRP in the brain and nerves. CGRP has been linked in studies to headaches like migraines and to nerve repair after injury. Because of these many roles, calcitonin and its related protein are studied for bone health, pain, and brain and nerve conditions.

Calcitonin as a medicine has been given by injection or nose spray, but swallowing it as a pill is hard because the stomach breaks it down. Scientists have tested ways to help peptide medicines survive the gut. Most strong evidence comes from animal and laboratory studies, and more human research is needed. Anyone thinking about hormone medicines should talk with a doctor first.

ApprovedApproved by a regulator (e.g. FDA) for a specific medical use — the highest research-status tier. High confidence60–79 — backed by solid sources with good corroboration across multiple citations.

Benefits

What Calcitonin Helps With

The benefits people report — backed by research.

Musculoskeletal (8)

Reduces blood calcium levels by inhibiting osteoclast activity 72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 srcBone repair 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 srcCalcitonin regulates calcium balance 72/100Rated 72/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcControl of symptoms and disease activity in Paget's disease 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Calcitonin has a role in calcium balance 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Calcitonin reduces blood calcium levels 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Bisphosphonates reduce blood calcium levels in hypercalcaemia 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Denosumab used in treatment of hypercalcaemia 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Reproductive & hormonal (7)

Calcitonin has a relatively minor role in calcium balance in humans 72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 srcCorticotrophin-releasing hormone drives the body's stress response 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 srcGrowth hormone therapy in childhood-onset deficiency helps achieve relatively normal height and development 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Growth hormone therapy helps children with GH deficiency achieve normal height 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Somatostatin inhibits secretion of various endocrine hormones 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Corticotrophin-releasing hormone is the main element driving the body's stress response 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Growth hormone deficiency treatment allows children to achieve relatively normal height and development 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Glycemic & metabolic (4)

Rapid lowering of blood calcium levels in severe hypercalcemia emergencies 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Calcitonin acts to reduce blood calcium levels 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Calcitonin used rarely as a medication to help manage severe hypercalcaemia 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Insulin sensitivity 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Cancer / tumor (3)

Calcitonin as a biomarker for Medullary Thyroid Carcinoma 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Calcitonin levels predict disease-free survival in hereditary MTC 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Diagnosis and monitoring of Medullary Thyroid Carcinoma 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Gastrointestinal & gut (2)

Cholecystokinin aids digestion and reduces appetite after a meal 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 srcCholecystokinin aids digestion and reduces appetite 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 src

Antimicrobial & antiviral (2)

Antimicrobial peptide design against KatG using molecular docking 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Peptide analogs induce multi-aggregate formation and impair cell division in Candida albicans 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

More reported benefits (5)

Decreases calcium reabsorption in the kidneys 72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 srcCorticotrophin-releasing hormone is the main element driving the body's response to stress 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 srcImmune modulation 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 srcGrowth hormone therapy in childhood-onset deficiency helps children achieve relatively normal height and development 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Novel melittin-based inhibitor of tyrosinase and MITF using machine-learning 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

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Safety

Known Side Effects

Adverse effects reported in the research and by community use.

  • C-cell Hyperplasia (Rodents)Moderate 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ pubmed.ncbi.nlm.nih.gov
  • TachyphylaxisModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Hypocalcemia following total thyroidectomy for MTCModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Impaired kidney function from bisphosphonatesModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Worsening of heart failure symptoms from excessive fluid replacementSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Low blood calcium levels following parathyroid surgeryModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Excessive fluid replacement worsening heart failure symptomsModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Bisphosphonates causing impaired kidney functionModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Low blood calcium following parathyroid surgeryModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info

Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.

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Evidence

Research Citations (41)

Every claim above traces back to a source you can check — here are 41 of them.

  • CALCA calcitonin related polypeptide alpha [ Homo sapiens (human) ]

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calca calcitonin/calcitonin-related polypeptide, alpha [ Mus musculus (house mouse) ]

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Evidence for Conservation of the Calcitonin Superfamily and Activity-regulating Mechanisms in the Basal Chordate Branchiostoma floridae: INSIGHTS INTO THE MOLECULAR AND FUNCTIONAL EVOLUTION IN CHORDATES.

    2016 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin, the forgotten hormone: does it deserve to be forgotten?

    2015 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin and human renal calcium and electrolyte transport.

    1997 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice.

    2008 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin plays a critical role in regulating skeletal mineral metabolism during lactation.

    2006 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.

    1986 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin-a hormone from the parathyroid which lowers the calcium-level of the blood.

    1962 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • THYROID ORIGIN OF CALCITONIN.

    1964 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Altered expression of the calcitonin gene associated with RNA polymorphism.

    1981 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin mRNA polymorphism: peptide switching associated with alternative RNA splicing events.

    1982 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Calcitonin in phantom limb pain.

    1999 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • the original

    90/100Rated 90/100Source typeRegulator or clinical registryIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Salmon calcitonin in the treatment of elderly women with type 2 diabetes complicated with osteoporosis.

    2014 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

Timeline

History & Milestones

Key moments in Calcitonin’s research and regulatory timeline — sourced and dated.

  1. Calcitonin and calcitonin receptorsPublicationMay 1, 2007
    Related:Calcitonin
    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source
  2. Calcitonin and calcitonin receptors: bone and beyondPublicationDec 1, 2000
    Related:Calcitonin
    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

News

Latest on Calcitonin

Dated, sourced reporting that mentions Calcitonin.

ResearchJul 19, 2024

The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer

A Nature Communications study shows that medullary thyroid cancer (MTC) expresses CGRP, which shapes an immunosuppressive tumor microenvironment by altering dendritic cell development via cAMP/KLF2 pathways and impairing T cell activity. A CGRP receptor antagonist reversed these effects in vitro. The findings propose the CGRP receptor as a potential therapeutic target in MTC.

72/100Rated 72/100Source typeEstablished referenceIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →

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