CagriSema bests tirzepatide for weight loss in type 2 diabetes

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September 21, 2026↗ source

Novo Nordisk announced topline results showing CagriSema, a fixed-dose combination of cagrilintide and semaglutide, produced greater weight loss than tirzepatide in adults with type 2 diabetes in the REIMAGINE 5 trial (12.4% vs. 9.1% at 60 weeks), while achieving noninferior HbA1c reductions. In the REDEFINE 9 trial, CagriSema led to 21% weight loss at 68 weeks in adults with overweight or obesity without diabetes. These are topline company-announced results from ongoing trial programs.

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SemaglutideTirzepatideLiraglutideGLP-1 receptor agonistsCagrilintideGLP-1MetforminAmylinBINACagrilintide + SemaglutideSGLT2 inhibitorsGLP-1RSGLT2 inhibitor
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