SS-31 vs BPC-157
SS-31 vs BPC-157: mitochondrial protection vs broad tissue repair — different repair strategies compared. Here's a neutral, sourced side-by-side — no hype, every claim links to its evidence.
SS-31
ApprovedAlso: SS-31 with Mitochondrial Cofactors, SS-31 and MOTS-c Combination
SS-31 is a small lab-made protein fragment, also called a peptide. It is sold as a white powder in small glass bottles for lab research.
BPC-157
ResearchAlso: Body Protection Compound, PL 14736
BPC-157 is a man-made copy of a tiny piece of protein found in the juice of your stomach. The letters stand for Body Protection Compound, and 157 is the number of the piece scientists found.
At a Glance
| SS-31 | BPC-157 | |
|---|---|---|
| Research status | Approved | Preclinical |
| Highest-tier evidence | Peer-reviewed study | Peer-reviewed study |
| Research citations | 3 | 50 |
| Dosing routes | SubQ | SubQ |
| Receptor targets | — | Growth Hormone Receptor, VEGF |
| Half-life | — | No established half-life in humans; preclinical data only. |
| Known side effects | 4 | 28 |
Research Areas
Top preclinical research areas — cited studies for each.
SS-31
- Treatment of Primary Mitochondrial Myopathy
- Improves physiological function in aging muscle
- Rescues muscle force
- Improves heart systolic function
- Increases ATP production
BPC-157
- Tendon/ligament repair
- Angiogenesis
- Anti-inflammatory
How People Use It
Reported routines — research only, not medical advice.
SS-31
Not yet documented for SS-31 — being compiled.
BPC-157
- SubQ — 5 mg BPC-157 + 5 mL BAC water
- SubQ — Daily
- SubQ — BPC-157 250–500 mcg/day SC + TB-500 2–5 mg twice weekly for 4–6 week loading, then TB-500 2 mg weekly for 4–8 weeks
The Evidence
Key studies — click through to verify each on PubMed.
SS-31
3 sourced studies
- Source
Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy.
2016 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age.
2017 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins.
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
BPC-157
50 sourced studies
- Source
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.
In vitro2010 Key study 85/100Rated 85/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing.
Review2019 80/100Rated 80/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts
In vitro2018 84/100Rated 84/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing
Review2025 76/100Rated 76/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
Decision Guide
How to Choose
Neither is a “winner” — they suit different goals. Compare the documented benefits and evidence above against what you’re actually trying to achieve, note the research status (approved vs research-stage), and read each full guide before deciding. Many people also stack peptides rather than pick one.
Source SS-31
Shop SS-31Source BPC-157