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Vasopressin

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Also called: [Arg8]-Vasopressin (AVP), Argipressin Acetate, Arginine Vasotocin

By The Health Stacks Research TeamUpdated September 3, 2026

Vasopressin is a natural hormone found in the body that helps control water balance and blood pressure. It is often used by doctors in hospital settings to help patients who are in shock or have very low blood pressure. This medicine works by making the blood vessels squeeze tighter, which helps push blood to important organs like the heart and brain. It is a powerful tool that is usually given through a needle into a vein by a trained medical team. The main way this drug works is by tightening the blood vessels to raise blood pressure quickly.

It is often used when other drugs or fluids are not enough to keep the body stable. It can also help the body hold onto water, which stops the patient from getting too dehydrated. Because it acts on the muscles in the blood vessel walls, it helps blood flow better when the body is in distress. This makes it very useful for treating severe bleeding or serious heart problems. While this drug is very helpful in emergencies, it must be used with great care.

It can cause the blood pressure to get too high or reduce blood flow to the heart or stomach if not watched closely. Doctors usually give it for a short time during critical moments rather than for long periods. It is not used for simple headaches or minor issues. Patients need to be watched closely to make sure their heart and other organs stay safe while getting this medicine.

ApprovedApproved by a regulator (e.g. FDA) for a specific medical use — the highest research-status tier. Verified confidence80–100 — backed by strong, well-corroborated sources (peer-reviewed research, clinical guidelines). Our highest confidence tier.

Benefits

What Vasopressin Helps With

The benefits people report — backed by research.

Renal & hepatic (6)

Conserves fluid volume by reducing water excreted in urine 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Adrenaline treats severe allergic reactions 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Conserves fluid volume by reducing water passed out in urine 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduces water loss by stimulating kidneys to produce concentrated urine 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Antidiuretic potency 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduces portal pressure and redistributes blood flow to kidneys 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Cardiovascular & vascular (3)

Increases blood pressure by constricting blood vessels at higher concentrations 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Controls blood pressure by constricting blood vessels at higher concentrations 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Water homeostasis and hemodynamic stability 60/100Rated 60/100Source typeSpecialist communityIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Musculoskeletal (2)

Bone repair 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Tendon/ligament repair 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Weight management (2)

Ghrelin increases appetite and stimulates growth hormone release 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Peptide YY reduces appetite and limits food intake 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Reproductive & hormonal (2)

Oxytocin controls childbirth and lactation 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Co-peptin measurement serves as a diagnostic biomarker to estimate AVP levels and differentiate AVP-Deficiency from AVP-Resistance 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

More reported benefits (7)

Induction of courtship behavior 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Modulation of olfactory response to female odors 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Fever induction as a defense mechanism 75/100Rated 75/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Vasopressin regulates water balance by preventing the excretion of large amounts of dilute urine 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Vasopressin controls water balance and prevents polyuria 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Optimization of lymphoid cell function at elevated temperatures 75/100Rated 75/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Insulin sensitivity 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

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How People Use It

1 reported routine — each line links to the source it came from.

From published sources

Routines as reported in peer-reviewed papers, clinical guidance, or vetted media — each linked to the source it came from.

SubQ

  • 50 or 100 µg 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.

Safety

Known Side Effects

Adverse effects reported in the research and by community use.

  • Hyponatraemia (low blood salt concentration from excessive water retention)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Dehydration and drop in blood pressure from insufficient ADH or kidney insensitivityModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Hyponatraemia (low blood sodium concentration from excessive water retention)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Dehydration and excessive urination (from insufficient AVP or kidney insensitivity)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • HeadachesModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Low sodium levels (hyponatremia) and fluid retention from desmopressin overdoseSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Seizures caused by desmopressin administration in misdiagnosed Primary PolydipsiaSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • Dizziness and indigestion from diuretics and NSAIDsMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • nauseaModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
  • and vomiting from desmopressinModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info

Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.

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Evidence

Research Citations (55)

Every claim above traces back to a source you can check — here are 55 of them.

  • Perturbations of arginine vasopressin secretion during inflammatory stress. Pathophysiologic implications.

    2000 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • AVP arginine vasopressin [ Homo sapiens (human) ]

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Avp arginine vasopressin [ Mus musculus (house mouse) ]

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Vasopressin and oxytocin gene expression in the human hypothalamus

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Vasopressin and oxytocin gene expression in the human hypothalamus.

    1993 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior.

    2010 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Physiology, Vasopressin

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Physiology, Vasopressin.

    2023 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Vasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole.

    2004 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Vasopressin and the regulation of aquaporin-2

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Vasopressin and the regulation of aquaporin-2.

    2013 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Regulation of renal urea transport by vasopressin

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Regulation of renal urea transport by vasopressin.

    2011 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Regulation of thick ascending limb transport by vasopressin

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

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