Vasopressin
Shop VasopressinAlso called: [Arg8]-Vasopressin (AVP), Argipressin Acetate, Arginine Vasotocin
Vasopressin is a natural chemical messenger in the body. It is also called the antidiuretic hormone. It is a small chain of building blocks called amino acids, joined together like beads on a string. Doctors sometimes use it as a medicine. It helps the body hold on to water and tightens blood vessels.
Vasopressin works in two main ways. First, it tells the kidneys to save water instead of sending it out in urine. This is why it is called an antidiuretic. Second, it squeezes blood vessels, which can raise blood pressure. Because of these jobs, it has been used to help stop bleeding and to support blood pressure.
Scientists have also studied putting vasopressin-type medicines in pill form, which is hard because the stomach usually breaks down peptides. Researchers agree that vasopressin is a real and important hormone, and it is an approved medicine in some forms. But most of the sources here only mention it briefly, so details about the best amounts to use and side effects are not well covered. Anyone thinking about using it should work with a licensed doctor, since too much can cause water buildup in the body and other problems.
Benefits
What Vasopressin Helps With
The benefits people report — backed by research.
Renal & hepatic (6)
Cardiovascular & vascular (3)
Musculoskeletal (2)
Weight management (2)
Reproductive & hormonal (2)
More reported benefits (7)
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How People Use It
1 reported routine — each line links to the source it came from.
From published sources
Routines as reported in peer-reviewed papers, clinical guidance, or vetted media — each linked to the source it came from.
SubQ
- 50 or 100 µg 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source
mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.
Safety
Known Side Effects
Adverse effects reported in the research and by community use.
- Hyponatraemia (low blood salt concentration from excessive water retention)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- Dehydration and drop in blood pressure from insufficient ADH or kidney insensitivityModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- Hyponatraemia (low blood sodium concentration from excessive water retention)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- Dehydration and excessive urination (from insufficient AVP or kidney insensitivity)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- HeadachesModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- Low sodium levels (hyponatremia) and fluid retention from desmopressin overdoseSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- Seizures caused by desmopressin administration in misdiagnosed Primary PolydipsiaSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- Dizziness and indigestion from diuretics and NSAIDsMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- nauseaModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
- and vomiting from desmopressinModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.
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Evidence
Research Citations (43)
Every claim above traces back to a source you can check — here are 43 of them.
- Source
Perturbations of arginine vasopressin secretion during inflammatory stress. Pathophysiologic implications.
2000 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
AVP arginine vasopressin [ Homo sapiens (human) ]
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Avp arginine vasopressin [ Mus musculus (house mouse) ]
95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Vasopressin and oxytocin gene expression in the human hypothalamus.
1993 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior.
2010 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Physiology, Vasopressin.
2023 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Vasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole.
2004 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Vasopressin and the regulation of aquaporin-2.
2013 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Regulation of renal urea transport by vasopressin.
2011 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Regulation of thick ascending limb transport by vasopressin.
1999 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC.
2013 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Angiotensin II-stimulated secretion of arginine vasopressin is inhibited by atrial natriuretic peptide in humans.
2011 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Vasopressin stimulation of adrenocorticotropin hormone (ACTH) in humans. In vivo bioassay of corticotropin-releasing factor (CRF) which provides evidence for CRF mediation of the diurnal rhythm of ACTH.
1988 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Noxious somatic stimuli excite neurosecretory vasopressin cells via A1 cell group.
1990 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology → - Source
Intraoperative changes in blood pressure, heart rate, plasma vasopressin, and urinary noradrenalin during elective ovariohysterectomy in dogs: repeatability at removal of the 1st and 2nd ovary.
2014 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
News
Latest on Vasopressin
Dated, sourced reporting that mentions Vasopressin.
Determination That VASOPRESSIN IN SODIUM CHLORIDE (vasopressin) 0.9%, Injection, 50 units/50 milliliters (1 unit/milliliters) Was Not Withdrawn From Sale for Reasons of Safety or Effectiveness
FDA determined that vasopressin in 0.9% sodium chloride injection, 50 units/50 mL (1 unit/mL) in a single-dose ready-to-use container, was not withdrawn from sale for reasons of safety or effectiveness. The determination clears the way for FDA to approve abbreviated new drug applications (ANDAs) for generic versions of the premixed vasopressin product if all other legal and regulatory requirements are met. The notice was filed under Docket No. FDA-2026-P-0525 and opens a path to expanded generic supply of the premixed formulation used in vasodilatory shock.
Drug Shortage Detail: Vasopressin Injection
ASHP's live entry documents the ongoing vasopressin injection shortage and its supplier dynamics: Baxter has vasopressin premixed bags on shortage due to increased demand, Par's Vasostrict 1 mL vials and 100 mL premixes are back-ordered with no release estimate, and Eagle has discontinued vasopressin injection. American Regent, Amneal, Amphastar, Eugia, Fresenius Kabi, Long Grove (premixed vials) and Sagent have product available.
Wondering how Vasopressin pricing compares across suppliers? Our original market data shows the full picture.
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