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teduglutide

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Also called: teduglutide

By The Health Stacks Research TeamUpdated September 16, 2026

Teduglutide is a man-made copy of a natural body chemical called GLP-2, a hormone made in the gut. It is a real medicine that has been approved for use in people.

It is given as a shot under the skin. It is used mostly by people with short bowel syndrome, a serious condition where a person has lost a large part of their intestine, often from surgery or disease.

These people often cannot get enough food and water on their own and need feeding through a vein, called parenteral nutrition.

ApprovedApproved by a regulator (e.g. FDA) for a specific medical use — the highest research-status tier. Verified confidence80–100 — backed by strong, well-corroborated sources (peer-reviewed research, clinical guidelines). Our highest confidence tier.

Benefits

What teduglutide Helps With

The benefits people report — backed by research.

Gastrointestinal & gut (9)

Treatment of Short Bowel Syndrome 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcTeduglutide reduces need for parenteral support in short bowel syndrome with intestinal failure 92/100Rated 92/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Treatment of Irritable Bowel Syndrome with Constipation 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →GLP-2 is an intestinotrophic mediator / most important trophic hormone of the small intestine 88/100Rated 88/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Teduglutide used in treatment of pediatric short bowel syndrome 80/100Rated 80/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Teduglutide reduces parenteral nutrition volume and infusion time in short bowel syndrome 72/100Rated 72/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Growth hormone, glutamine, and optimal diet reduces parenteral nutrition in SBS patients 70/100Rated 70/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Intestinal adaptation over ~2 years via L-cell hormones; hormone analogs accelerate rehabilitation 68/100Rated 68/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Teduglutide can enable full transition to enteral autonomy 65/100Rated 65/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

More reported benefits (10)

Treatment of Perianal Fistulizing Crohn's Disease 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Treatment of Crohn's Disease 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Treatment of Refractory Celiac Disease 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Treatment of Refractory Celiac Disease Type II 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →GLP-2 analogues enable reducing PN requirements in formerly PN-dependent patients 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Clonidine reduces diarrhea and sodium loss in patients with proximal jejunostomy 72/100Rated 72/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Anti-inflammatory 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Immune modulation 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →GLP-2 analog use reduces PN-related risks and improves quality of life and prognosis 65/100Rated 65/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Teduglutide is a recombinant 33-amino acid GLP-2 analogue promoting intestinal growth in short bowel syndrome 60/100Rated 60/100Source typeSpecialist communityIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →

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How People Use It

1 reported routine — each line links to the source it came from.

Self-reported & vendor-suggested

Routines shared by users and sellers in forums and product pages — anecdotal, not tested in clinical trials. We show them for completeness, not as a recommendation.

SubQ

  • Subcutaneous injection 60/100Rated 60/100Source typeSpecialist communityIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.

Safety

Known Side Effects

Adverse effects reported in the research and by community use.

  • Serious Adverse EventsSevere 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source
  • Potential toxicity of parenteral vitamin preparationsModerate 70/100Rated 70/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ doi.org

Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.

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Evidence

Research Citations (2)

Every claim above traces back to a source you can check — here are 2 of them.

  • Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome.

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

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