Secretin

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By The Health Stacks Research TeamUpdated September 20, 2026

Secretin is a natural body chemical called a hormone. It is made by special cells in the wall of the small intestine. When food leaves the stomach, it carries acid with it. Secretin tells the pancreas and liver to send out watery fluids. These fluids are full of baking-soda-like stuff that calms down the acid.

Secretin works like a messenger. It rides in the blood to reach the pancreas. There, it makes the pancreas send out a lot of fluid that protects the intestine from burning acid. Doctors have used it in special tests to see how well the pancreas works. Some parents of children with autism have tried it, hoping it would help.

Scientists know a lot about what secretin does in the body. But they are still not sure it helps with anything outside normal digestion. Studies did not show clear benefits for autism. Using it as a treatment is not proven, so people should talk to a doctor first.

ApprovedApproved by a regulator (e.g. FDA) for a specific medical use — the highest research-status tier. Verified confidence80–100 — backed by strong, well-corroborated sources (peer-reviewed research, clinical guidelines). Our highest confidence tier.

Benefits

What Secretin Helps With

The benefits people report — backed by research.

Gastrointestinal & gut (15)

Stimulation of pancreatic fluid and bicarbonate secretion 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Gastric / gut lining 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Stimulation of pancreatic exocrine secretion of bicarbonate, water, and electrolytes 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Potentiation of enzyme secretion by acinar cells 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Regulation of pancreatic ducts 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Regulation of pancreatic exocrine function 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Regulation of pancreatic secretion 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Stimulates biliary and pancreatic ductular bicarbonate and water secretion 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Inhibition of pancreatic fluid secretion 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Potentiates CCK action on pancreatic acinar cells 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Diagnostic tool for gastrinoma 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Potentiation of exocrine secretory effect of cholecystokinin 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Stimulates bicarbonate secretion from pancreas and bile ducts 72/100Rated 72/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Neutralizes acid in the small intestine 72/100Rated 72/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Diagnosis of exocrine pancreatic disorders 72/100Rated 72/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Weight management (5)

Activates brown adipose tissue glucose uptake 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Delays motivation to refeed after a meal 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Induces satiation and appetite suppression 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Promotes lipolysis in white adipose tissue 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Activates thermogenesis in brown adipose tissue 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Energy & mitochondrial (2)

Energy metabolism 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Luminal ATP enhances HCO3- and fluid secretion while basolateral ATP inhibits secretion via purinoceptors 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

More reported benefits (15)

Stimulation of pancreatic HCO3- and fluid secretion 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Regulates pH of duodenal contents 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Stimulates somatostatin secretion from the pancreas 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Secretin evokes secretion of HCO3-rich pancreatic juice in all species 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Isolated guinea-pig pancreatic ducts respond to physiological concentrations of secretin 88/100Rated 88/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Serotonin by isolated pancreatic ducts via 5-HT3 receptor 88/100Rated 88/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Low concentrations of ethanol enhance secretin-stimulated fluid secretion in guinea-pig pancreatic ducts, maximal at 1 mM 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →CaSR agonist Gd3+ stimulates HCO3- secretion in rat pancreatic duct, potentially preventing CaCO3 precipitation 82/100Rated 82/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Regulation of intraductal pressure 80/100Rated 80/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Brain / cognitive 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Regulation of fluid homeostasis via renal and central nervous system effects 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Insulin sensitivity 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Increases cardiac output and renal blood flow via vasodilation 80/100Rated 80/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Insulin sensitivity 75/100Rated 75/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Treatment of peptic ulcers 72/100Rated 72/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

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How People Use It

1 reported routine — each line links to the source it came from.

From published sources

Routines as reported in peer-reviewed papers, clinical guidance, or vetted media — each linked to the source it came from.

SubQ

  • 1-10 pM (physiological concentrations) 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources6Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.

Safety

Known Side Effects

Adverse effects reported in the research and by community use.

  • Allergic reactionModerate 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ pancreapedia.org
  • Attenuated insulin secretion and increased glucagon secretionModerate 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ doi.org

Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.

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Evidence

Research Citations (37)

Every claim above traces back to a source you can check — here are 37 of them.

  • SCT secretin [ Homo sapiens (human) ]

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Sct secretin [ Mus musculus (house mouse) ]

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Secretin.

    1980 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Secretin: structure of the precursor and tissue distribution of the mRNA.

    1990 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA.

    2000 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Processing of prosecretin: isolation of a secretin precursor from porcine intestine.

    1990 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption.

    2007 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Secretin as a neurohypophysial factor regulating body water homeostasis.

    2009 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Secretin and the exposition of hormonal control.

    2004 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Secretin--the first hormone

    2002 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Immunofluorescent localization of secretin and enteroglucagon in human intestinal mucosa.

    1971 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Plasma secretin concentrations and gastric pH in healthy subjects and patients with digestive diseases.

    1981 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Exocrine pancreatic secretion and immunoreactive secretin (IRS) release after intraduodenal instillation of bile in man.

    1978 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • The gastrointestinal stimulus to insulin release. II. A dual action of secretin.

    1970 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

  • Secretin causes H+/HCO3- secretion from pig pancreatic ductules by vacuolar-type H(+)-adenosine triphosphatase.

    1995 95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

News

Latest on Secretin

Dated, sourced reporting that mentions Secretin.

Research

The secretin-autism question settled by a controlled trial: no benefit

After thousands of families sought secretin injections for autism following anecdotal TV reports, a double-blind NEJM trial (Sandler et al., 9 December 1999) tested a single dose of synthetic human secretin in 60 children and found no benefit over placebo on any behavioral or language measure - a landmark negative result for evidence over anecdote.

95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →
Research

Secretin: the first hormone

A Danish review in Ugeskrift for Laeger traces secretin from the 1902 Bayliss-Starling discovery through a century of physiology: pancreatic function testing, the water-regulation role discovered decades later, and why this 27-amino-acid gut hormone remains the textbook opening chapter of endocrinology.

95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →
Research

Bayliss and Starling describe secretin - the experiment that launched the hormone concept

In a Journal of Physiology paper dated 12 September 1902, William Bayliss and Ernest Starling showed that acid in the duodenum releases a chemical messenger into the blood that drives the pancreas to secrete. They named it secretin - and coined the word hormone for this new class of blood-borne signals, founding modern endocrinology.

95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →

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