Rosuvastatin

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By The Health Stacks Research TeamUpdated September 18, 2026

Rosuvastatin is a medicine called a statin. Its brand name is Crestor. It comes as a pill you swallow. Doctors give it to people who have high cholesterol or who are at high risk for heart problems like heart attacks and strokes. It is sold only with a doctor's prescription in the US, UK, Canada, and Australia.

Rosuvastatin works by blocking a substance in the liver that the body uses to make cholesterol. With less cholesterol made, the liver pulls cholesterol out of the blood. This lowers the 'bad' cholesterol called LDL. Studies show it can lower the chance of stroke, heart problems, and death. It also lowers other heart-risk markers in the blood.

People should use it along with healthy eating, exercise, and weight loss. Most side effects are mild, like stomach pain, nausea, headaches, and muscle aches. Rare but serious problems include muscle breakdown, liver trouble, and higher blood sugar. It may harm an unborn baby, so pregnant women should not take it. Grapefruit juice can interfere with the drug, and some other medicines need dose changes. Talk to a doctor before starting or stopping this medicine.

ApprovedApproved by a regulator (e.g. FDA) for a specific medical use — the highest research-status tier. Verified confidence80–100 — backed by strong, well-corroborated sources (peer-reviewed research, clinical guidelines). Our highest confidence tier.

Benefits

What Rosuvastatin Helps With

The benefits people report — backed by research.

Cardiovascular & vascular (4)

Angiogenesis 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →50% reduction in LDL cholesterol levels 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduced risk of myocardial infarction 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduced risk of stroke 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Anti-inflammatory (1)

37% reduction in high-sensitivity C-reactive protein levels 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

More reported benefits (1)

Reduced all-cause mortality 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

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How People Use It

1 reported routine — each line links to the source it came from.

From published sources

Routines as reported in peer-reviewed papers, clinical guidance, or vetted media — each linked to the source it came from.

SubQ

  • 20 mg daily 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.

Safety

Known Side Effects

Adverse effects reported in the research and by community use.

  • Increased incidence of physician-reported diabetesModerate 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ pubmed.ncbi.nlm.nih.gov
  • Elevated reporting of ALS and ALS-like conditions (disproportionality signal)Severe 80/100Rated 80/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ doi.org
  • Motor neuron disease reporting signal with simvastatinSevere 78/100Rated 78/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ doi.org
  • Statin-associated myopathy (including with normal creatine kinase levels)Moderate 75/100Rated 75/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ doi.org
  • Immune-mediated necrotizing myopathyModerate 75/100Rated 75/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ doi.org
  • Mitochondrial myopathyModerate 70/100Rated 70/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ doi.org

Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.

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