Peptide YY
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Also called: YY (PYY) (3-36), human, YY (PYY) (3-36), human TFA, YY (PYY) (3-36), human acetate
By The Health Stacks Research TeamUpdated September 19, 2026
Peptide YY is a natural chemical messenger made by cells in the lining of your gut. Your body makes it after you eat. It is not a drug you buy, but a hormone your own body produces. Peptide YY helps tell your brain that you are full.
After a meal, gut cells release it into the blood. It travels to the brain and helps lower hunger, so you stop eating. It works alongside other fullness and hunger signals your body uses to balance energy and body weight. Scientists are still learning how Peptide YY works and how to use it safely as a medicine.
Most of what is known comes from lab and animal studies, with less proof in people. No Peptide YY drug is approved for weight loss, and taking hormone-like products without a doctor can be risky. More human research is needed before clear claims can be made.
Research-stageEarly-stage — evidence so far is mostly cell, animal, or preliminary human studies. Not an approved medicine. High confidence60–79 — backed by solid sources with good corroboration across multiple citations.
Benefits
What Peptide YY Helps With
The benefits people report — backed by research.
Weight management (13)
Reduces appetite and limits food intake 72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 srcPeptide YY reduces appetite and limits food intake 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 3 srcReduction of food intake 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Weight management 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Induces satiety and reduces food intake 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reverses protein-diet induced obesity resistance in knockout models 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduces appetite and food intake 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Peptide YY plays a role in appetite regulation and food intake 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Potential therapeutic agent for obesity 80/100Rated 80/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Increases appetite and stimulates release of growth hormone 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Appetite reduction and food intake limitation 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Treatment of obesity 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Satiety signaling regulation 60/100Rated 60/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →
Gastrointestinal & gut (13)
Inhibits exocrine pancreatic secretion 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Attenuation of nausea and emesis 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Gastric / gut lining 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Inhibits pancreatic exocrine secretion 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Inhibits intestinal transit 90/100Rated 90/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Stimulates intestinal growth 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Endogenous inhibitor of diarrhea 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Functions as a feedback inhibitor of pancreatic secretion after a meal 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Feedback inhibitor of pancreatic secretion after a meal 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Weight management 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Slows down the movement of food through the digestive tract 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Regulates molecules secreted by the pancreas 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Depresses intestinal secretion and motility 60/100Rated 60/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →
Glycemic & metabolic (4)
Insulin sensitivity 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcGlucagon regulates blood glucose levels in response to protein-rich meals, exercise, and starvation 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Glucagon is important in regulating molecules secreted by the pancreas and responds to blood glucose changes 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Treatment of metabolic disorders 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →
Reproductive & hormonal (3)
Parathyroid hormone is the most important regulator of blood calcium levels 72/100Rated 72/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcEssential for reproductive hormone secretion and fertility 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Inhibits the release of growth hormone and other hormones 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →
More reported benefits (8)
Immune modulation 72/100Rated 72/100Source typeEstablished referenceIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcRelaxation of the gallbladder 75/100Rated 75/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Treatment of alimentary tract disorders 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Treatment of nervous system disorders 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Somatostatin inhibits the secretion of various endocrine hormones 70/100Rated 70/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Tendon/ligament repair 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Anti-inflammatory 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Stimulates growth hormone release 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →
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Safety
Known Side Effects
Adverse effects reported in the research and by community use.
- Nausea and vomitingModerate 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ pmc.ncbi.nlm.nih.gov
- Malaise (nausea-like behavior)Moderate 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ pmc.ncbi.nlm.nih.gov
- Decreased appetite and dramatic weight loss (from high PYY concentrations)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ yourhormones.info
Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.
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