Motixafortide
Shop MotixafortideMotixafortide is a medicine given as a shot under the skin. Its brand name is Aphexda. Doctors use it to help people with a blood cancer called multiple myeloma. It is approved for use in the United States. It was approved in September 2023.
Some people with multiple myeloma need a stem cell transplant that uses their own cells. Before the transplant, doctors need to collect stem cells from the blood. Motixafortide helps push stem cells out of the bone marrow and into the blood so they can be collected. It works by blocking a docking spot, called CXCR4, that keeps stem cells locked inside the bone marrow. Doctors give it together with another medicine called filgrastim, which also helps move stem cells into the blood.
Common side effects include soreness where the shot was given, itching, flushing, and back pain. It can also cause serious allergic reactions, so it is given in a setting where help is close by. A big study called GENESIS tested it in 122 people and found it helped collect stem cells. Scientists are also studying it for other uses, like sickle cell disease and pancreatic cancer, but those uses are not yet approved.
Benefits
What Motixafortide Helps With
The benefits people report — backed by research.
Immune modulation (2)
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How People Use It
1 reported routine — each line links to the source it came from.
From published sources
Routines as reported in peer-reviewed papers, clinical guidance, or vetted media — each linked to the source it came from.
SubQ
- 62 mg 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source
mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.
Safety
Known Side Effects
Adverse effects reported in the research and by community use.
- Injection site reactionsMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ clinicaltrialsarena.com
- PruritusMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ clinicaltrialsarena.com
- FlushingMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ clinicaltrialsarena.com
- Back painMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ clinicaltrialsarena.com
- Serious adverse reactionsSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ clinicaltrialsarena.com
Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.
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