macimorelin

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By The Health Stacks Research TeamUpdated September 19, 2026

Macimorelin is a medicine used by doctors to find out if a grown-up person's body is not making enough growth hormone. Growth hormone is a natural body chemical that helps with muscles, bones, and energy. Macimorelin comes as a drink you swallow, not a shot. Its brand name is Macrilen. Macimorelin works by copying a natural body signal called ghrelin.

Ghrelin tells a part of the brain called the pituitary gland to let out growth hormone. When a person drinks macimorelin after not eating for 8 hours, their growth hormone should rise fast. If it does not rise enough, the doctor knows the body likely has a growth hormone problem. Studies show this test works about as well as older tests that needed needles. Macimorelin was approved in the United States in 2017 for this test.

It can make the heart's rhythm slightly longer, so doctors check for heart risks first. Most people get it only once, for the test. It should only be used under a doctor's care. Some websites sell it for other uses, but those uses are not well proven and are not approved.

ApprovedApproved by a regulator (e.g. FDA) for a specific medical use — the highest research-status tier. High confidence60–79 — backed by solid sources with good corroboration across multiple citations.

Benefits

What macimorelin Helps With

The benefits people report — backed by research.

Performance & recovery (2)

Stimulates GH release by activating GH secretagogue receptors in the pituitary and hypothalamus 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Growth hormone replacement therapy improves maximal oxygen consumption and exercise capacity 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Musculoskeletal (2)

Muscle recovery 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Bone repair 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

More reported benefits (3)

Diagnosis of adult growth hormone deficiency 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Insulin sensitivity 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Angiogenesis 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

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How People Use It

1 reported routine — each line links to the source it came from.

From published sources

Routines as reported in peer-reviewed papers, clinical guidance, or vetted media — each linked to the source it came from.

SubQ

  • For a patient weighing 120 kg: Use 2 pouches 72/100Rated 72/100Source typeEstablished referenceIndependent sources3Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.

Safety

Known Side Effects

Adverse effects reported in the research and by community use.

  • DysgeusiaMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • DizzinessMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • HeadacheMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • FatigueMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • NauseaMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • HungerMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • DiarrheaMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • Upper respiratory tract infectionMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • Feeling hotMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • HyperhidrosisMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • NasopharyngitisMild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • Sinus bradycardiaModerate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • QT prolongationSevere 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ reference.medscape.com
  • Hypoglycemia symptoms during Insulin Tolerance Test (ITT)Moderate 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ emedicine.medscape.com
  • Dysgeusia (Taste distortion)Mild 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ link.springer.com

Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.

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