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Dulaglutide

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Also called: Trulicity (dulaglutide), LY2189265, AWARD

By The Health Stacks Research TeamUpdated September 7, 2026

Dulaglutide is a medicine used to help people with type 2 diabetes. It is a man-made copy of a hormone called GLP-1. This medicine is injected under the skin once a week. It helps the body make more insulin when blood sugar is high. It also helps the body make less sugar. It is often used when other pills for diabetes are not enough.

This medicine works by copying a natural hormone that controls appetite and digestion. It helps the body release insulin only when needed. This helps lower blood sugar levels after eating. It also helps people feel full sooner. This can lead to weight loss for some people. It helps keep blood sugar levels steady throughout the day.

Doctors know this medicine is good for blood sugar, but there are some things to watch out for. Some studies looked at whether it harms the eyes, but the results are mixed. It is not fully clear if it causes eye problems or if it is just a change in blood sugar. Common side effects include feeling sick to your stomach. You must stop taking it for some medical procedures. It is important to follow doctor's advice closely.

ApprovedApproved by a regulator (e.g. FDA) for a specific medical use — the highest research-status tier. High confidence60–79 — backed by solid sources with good corroboration across multiple citations.

Benefits

What Dulaglutide Helps With

The benefits people report — backed by research.

Glycemic & metabolic (7)

Glycemic control in Type 2 Diabetes 72/100Rated 72/100Source typeEstablished referenceIndependent sources5Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 5 srcManagement of glycaemic control in type 2 diabetes 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Lowers blood glucose 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Insulin sensitivity 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Improving lipid disorders 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Blocking glucagon secretion 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Suppressing glucagon 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Weight management (5)

Weight management 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduces appetite 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Increasing satiety 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Increased satiety 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Lowers preference for high calorie foods 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Renal & hepatic (5)

Delaying progression of nephropathy 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Liver health 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reducing risk of kidney disease 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduces risk of serious kidney complications by 18% 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduces risk of kidney failure by 16% 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Cardiovascular & vascular (4)

Angiogenesis 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcLowers blood pressure 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Lowering blood pressure 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reducing risk of heart disease 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Gastrointestinal & gut (3)

Gastric / gut lining 72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 srcSlowing stomach emptying 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Promotes mucosal healing and reduces proinflammatory cytokines in IBD 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Neuroprotection & cognitive (3)

Protects dopaminergic neurons in Parkinson's models 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Improves axonal function by boosting Na+/K+-ATPase pump activity 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Low-dose semaglutide may reduce alcohol cravings in alcohol use disorder 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

More reported benefits (3)

Angiogenesis 72/100Rated 72/100Source typeEstablished referenceIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Dulaglutide, semaglutide, and tirzepatide are the most effective agents in combination therapies for glycemic control 72/100Rated 72/100Source typeEstablished referenceIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Dulaglutide, semaglutide, and tirzepatide are the most effective GLP-1 agents in combination therapies 72/100Rated 72/100Source typeEstablished referenceIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →

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How People Use It

1 reported routine — each line links to the source it came from.

From published sources

Routines as reported in peer-reviewed papers, clinical guidance, or vetted media — each linked to the source it came from.

SubQ

  • Once a week 72/100Rated 72/100Source typeEstablished referenceIndependent sources19Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.

Safety

Known Side Effects

Adverse effects reported in the research and by community use.

Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.

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Evidence

Research Citations (1)

Every claim above traces back to a source you can check — here are 1 of them.

  • SEARCH RESULTS for: Dulaglutide (7 results)

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

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