Dulaglutide

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Also called: Trulicity (dulaglutide), LY2189265, AWARD

By The Health Stacks Research TeamUpdated September 20, 2026

Dulaglutide is a medicine known by the brand name Trulicity. It belongs to a group of drugs that copy a natural body signal called GLP-1, which helps control blood sugar. It is mostly used by adults with type 2 diabetes, a condition where the body has trouble managing sugar in the blood. It is given as a shot, usually once a week. Dulaglutide helps the body release insulin, which lowers blood sugar, and it also tends to help with weight loss.

New research suggests it may help with other health problems too. One big study found that people with lung conditions like asthma or COPD (a serious breathing disease) who took dulaglutide for diabetes had fewer breathing flare-ups. Another large study looked at people with bipolar disorder, a mental health condition, who also had diabetes. It found this group of medicines did not seem to cause mental health harms, which is a good safety sign. There is still a lot to learn.

The breathing study mainly highlighted semaglutide as having the strongest effect, and dulaglutide's benefits for lungs need more proof. The mental health study focused on semaglutide, so dulaglutide's role there is not fully clear. Dulaglutide is an approved prescription medicine, but it can cause side effects like stomach upset. Anyone thinking about using it should talk to a doctor first, because it is a strong drug that needs proper medical care.

ApprovedApproved by a regulator (e.g. FDA) for a specific medical use — the highest research-status tier. High confidence60–79 — backed by solid sources with good corroboration across multiple citations.

Benefits

What Dulaglutide Helps With

The benefits people report — backed by research.

Glycemic & metabolic (9)

Glycemic control in Type 2 Diabetes 72/100Rated 72/100Source typeEstablished referenceIndependent sources5Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 5 srcManagement of glycaemic control in type 2 diabetes 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Lowers blood glucose 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Insulin sensitivity 85/100Rated 85/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Improving lipid disorders 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Blocking glucagon secretion 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Suppressing glucagon 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Angiogenesis 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Dulaglutide, semaglutide, and tirzepatide are the most effective agents in combination therapies for glycemic control 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Weight management (5)

Weight management 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduces appetite 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Increasing satiety 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Increased satiety 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Lowers preference for high calorie foods 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Renal & hepatic (5)

Delaying progression of nephropathy 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Liver health 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reducing risk of kidney disease 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduces risk of serious kidney complications by 18% 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reduces risk of kidney failure by 16% 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Cardiovascular & vascular (4)

Angiogenesis 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources2Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 2 srcLowers blood pressure 95/100Rated 95/100Source typePeer-reviewed studyIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Lowering blood pressure 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Reducing risk of heart disease 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Gastrointestinal & gut (3)

Gastric / gut lining 72/100Rated 72/100Source typeEstablished referenceIndependent sources4Every claim links to the page it came from, and stronger sources rate higher. Full methodology →· 4 srcSlowing stomach emptying 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Promotes mucosal healing and reduces proinflammatory cytokines in IBD 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

Neuroprotection & cognitive (3)

Protects dopaminergic neurons in Parkinson's models 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Improves axonal function by boosting Na+/K+-ATPase pump activity 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Low-dose semaglutide may reduce alcohol cravings in alcohol use disorder 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →

More reported benefits (4)

Dulaglutide, semaglutide, and tirzepatide are the most effective GLP-1 agents in combination therapies 72/100Rated 72/100Source typeEstablished referenceIndependent sources1Every claim links to the page it came from, and stronger sources rate higher. Full methodology →Dulaglutide significantly reduced fluid intake and thirst in primary polydipsia versus placebo 82/100Rated 82/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Weight management 72/100Rated 72/100Source typeEstablished referenceIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Dulaglutide, semaglutide, and tirzepatide are most effective in combination therapies for glycemic control 72/100Rated 72/100Source typeEstablished referenceIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →

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How People Use It

1 reported routine — each line links to the source it came from.

From published sources

Routines as reported in peer-reviewed papers, clinical guidance, or vetted media — each linked to the source it came from.

SubQ

  • Once a week 72/100Rated 72/100Source typeEstablished referenceIndependent sources19Every claim links to the page it came from, and stronger sources rate higher. Full methodology →↗ source

mg vs mcg: one milligram (mg) equals 1,000 micrograms (mcg) — multiply by 1,000 going from mg to mcg, divide by 1,000 going from mcg to mg. Mixing the two up is a thousand-fold dosing error: 1 mg taken instead of 1 mcg is a 1,000× overdose; 1 mcg instead of 1 mg is a 1,000× underdose. Always double-check the unit label and the decimal place.

Safety

Known Side Effects

Adverse effects reported in the research and by community use.

Reported in research and community sources — not exhaustive. Discontinue use and consult a healthcare professional if side effects occur.

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Evidence

Research Citations (1)

Every claim above traces back to a source you can check — here are 1 of them.

  • SEARCH RESULTS for: Dulaglutide (7 results)

    95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →
    Source

News

Latest on Dulaglutide

Dated, sourced reporting that mentions Dulaglutide.

ResearchSep 14, 2026

Semaglutide linked to fewer exacerbations in asthma, COPD

An abstract presented at the 2026 European Respiratory Society International Congress links semaglutide use in patients with type 2 diabetes to fewer exacerbations in asthma (38% reduction) and COPD (21% reduction). Other GLP-1 receptor agonists like exenatide and dulaglutide also showed exacerbation reductions. The associations persisted regardless of weight or glycemic changes, suggesting possible direct lung anti-inflammatory effects.

50/100Rated 50/100Source typeUnclassified sourceIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →
Clinical

Dulaglutide biosimilar LY05008 matches Trulicity on HbA1c in phase 3 trial

A 440-patient phase 3 trial found Innovent's dulaglutide biosimilar LY05008 statistically equivalent to Trulicity for blood-sugar control in type 2 diabetes: HbA1c fell 1.44% versus 1.41% at 24 weeks, with similar safety and only about a quarter the hypoglycemia rate. With Trulicity's patent cliff behind it, results like this are how a $6-billion-a-year GLP-1 gets its cheaper copies.

95/100Rated 95/100Source typePeer-reviewed studyIndependent sourcesstill being verifiedEvery claim links to the page it came from, and stronger sources rate higher. Full methodology →Read →

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