A genome-wide association study published in Nature Communications has identified a genetic link between hyperemesis gravidarum (HG), a severe form of pregnancy sickness, and two specific genes: GDF15 and IGFBP7. The research found that variants at chr19p13.11 and chr4q12 loci are associated with the condition, implicating these genes which are known to influence placentation, appetite regulation, and cachexia. While further study is needed to prove causality, these findings suggest that hormonal signaling involving these peptides may drive the severe nausea and vomiting experienced in HG.
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