This clinical study investigated how a state of ketosis affects appetite-regulating hormones following significant weight loss. Researchers found that maintaining ketosis via a very-low-energy diet (VLED) suppressed the typical post-weight loss surge in ghrelin, a hormone known to stimulate hunger. Additionally, participants in ketosis exhibited lower levels of amylin and leptin compared to their levels after refeeding, suggesting that ketogenic diets may help mitigate the physiological drive to regain weight.
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