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Deficiency of the palmitoyl acyltransferase ZDHHC7 modulates depression-like behaviour in female mice after a mild chronic stress paradigm | Translational Psychiatry

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January 24, 2025↗ source

A study in *Translational Psychiatry* found that female mice lacking the ZDHHC7 gene exhibited resilience to chronic stress, characterized by reduced depression-like behaviors and preserved hippocampal structure. This resilience was associated with a significant upregulation of the neuropeptide cortistatin in the brain, suggesting a potential protective role for this peptide against stress-induced psychiatric disorders.

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StatinZDHHC7
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