Researchers have identified neuraminidase 1 (NEU1) as a novel regulator that suppresses the liver's response to glucagon, a peptide hormone that raises blood sugar. In mouse models, the absence of NEU1 exacerbated glucagon-driven glucose production, whereas its overexpression reduced hyperglycemia. The study also identified two compounds, α-hederin and oleanolic acid, that mimic this protective effect by stabilizing NEU1.