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A non-enzymatic function of neuraminidase 1 restrains hepatic glucagon response in mice | Nature Communications

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July 29, 2026↗ source

Researchers have identified neuraminidase 1 (NEU1) as a novel regulator that suppresses the liver's response to glucagon, a peptide hormone that raises blood sugar. In mouse models, the absence of NEU1 exacerbated glucagon-driven glucose production, whereas its overexpression reduced hyperglycemia. The study also identified two compounds, α-hederin and oleanolic acid, that mimic this protective effect by stabilizing NEU1.

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